| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Carbon ion radiotherapy (C-ion RT) is a potential therapy for radio-resistant malignant tumors. However, in cases of progressive malignant tumors, achieving a complete response is difficult. Therefore, chemotherapy (with an Hsp90 inhibitor, 17-AAG) in combination with C-ion RT was employed. This study was designed to clarify the cell killing effect of 17-AAG, in combination with X-rays or carbon-ion beams in oral squamous cell carcinoma cells. 17-AAG and X-rays in combination showed enhanced antitumor effect compared to C-ion RT, which had an adequate antitumor effect even when used alone. The difference in the effectiveness of the two combination therapies was attributable to the difference in their therapeutic mechanisms. At high doses, the difference between the invasive effect of the combination treatments and that of the individual treatments decreased. However, since 17-AAG shows sufficient combined effects even at low doses, we investigated the invasive effects at low doses.
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