Novel fluctuation MR imaging in idiopathic normal pressure hydrocephalus

• Project/Area Number: 25861076
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: OHNO Naoki 金沢大学, 保健学系, 助教 (30642219)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 磁気共鳴画像（MRI） / 特発性正常圧水頭症 / 水分子拡散 / 灌流 / バイオメカニクス / 頭蓋内環境 / 水分子揺動 / 血流 / MRI

Outline of Final Research Achievements

We developed a new fluctuation magnetic resonance imaging (MRI) which can provide functional information on brain compliance, perfusion, and tissue structure, and applied it to patients with idiopathic normal pressure hydrocephalus (iNPH). We clarified that our method may enable noninvasive and more detailed evaluation of intracranial biomechanics and assist in the diagnosis of iNPH.

Research Products

• [Journal Article] Hemodynamic analysis of cerebral water fluctuation in brain using diffusion and perfusion MRI (2016)
  • Author(s): Kitanaka A, Miyati T, Ohno N, Kan H, Mase M, Kobayashi S, Gabata T
  • Journal Title: Med Imag & Infor Sci Volume: 33 Pages: 7-11
  • Peer Reviewed
• [Journal Article] Modified Triexponential Analysis of Intravoxel Incoherent Motion for Brain Perfusion and Diffusion (2016)
  • Author(s): Ohno N, Miyati T, Kobayashi S, Gabata T
  • Journal Title: J Magn Reson Imaging Volume: 43 Issue: 4 Pages: 818-823
  • DOI: 10.1002/jmri.25048
  • Peer Reviewed
• [Journal Article] Triexponential function analysis of diffusion-weighted MRI for diagnosing prostate cancer (2016)
  • Author(s): Ueda Y, Takahashi S, Ohno N, Kyotani K, Kawamitu H, Miyati T, Aoyama N, Ueno Y, Kitajima K, Kawakami F, Okuaki T, Tsukamoto R, Yanagita E, Sugimura K
  • Journal Title: J Magn Reson Imaging Volume: 43 Issue: 1 Pages: 138-148
  • DOI: 10.1002/jmri.24974
  • Peer Reviewed
• [Journal Article] Current status of fluctuation magnetic resonance imaging (2015)
  • Author(s): Ohno N, Miyati T
  • Journal Title: Med Imag & Infor Sci Volume: 32 Pages: 33-36
  • NAID: 130005116572
  • Peer Reviewed
• [Journal Article] Dynamic changes in apparent diffusion coefficient of white matter and ventricular system during cardiac cycle in idiopathic normal pressure hydrocephalus (2015)
  • Author(s): Ohno N, Mase M, Miyati T, Osawa T, Alperin N, Kasai H, Hiratsuka S, Kawano M, Shibamoto Y, Kobayashi S, Gabata T, Matsui O
  • Journal Title: Med Imag & Infor Sci Volume: 32 Pages: 47-53
  • NAID: 130005116566
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Quantitative assessment of tissue perfusion in hepatocellular carcinoma using perflubutane dynamic contrast-enhanced ultrasonography (2015)
  • Author(s): Ohno N, Miyati T, Yamashita M, Narikawa M
  • Journal Title: Diagnostics Volume: 5 Issue: 2 Pages: 210-218
  • DOI: 10.3390/diagnostics5020210
  • Peer Reviewed / Open Access
• [Journal Article] Simultaneous <i>T₂</i> and biexponential diffusion analysis in breast lesion (2015)
  • Author(s): Takanaga M, Miyati T, Ohno N, Kawashima M, Hayashi N, Matsuura Y, Gabata T
  • Journal Title: Medical Imaging and Information Sciences Volume: 32 Issue: 1 Pages: 1-7
  • DOI: 10.11318/mii.32.1
  • NAID: 130005062291
  • ISSN: 0910-1543, 1880-4977
  • Peer Reviewed
• [Journal Article] State of water molecular displacement of the brain during the cardiac cycle in idiopathic normal pressure hydrocephalus (2015)
  • Author(s): Kan H
  • Journal Title: Comput Med Imaging Graph Volume: 40 Pages: 88-93
  • DOI: 10.1016/j.compmedimag.2014.12.004
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Evaluation of perfusion-related and true diffusion in vertebral bone marrow: a preliminary study (2015)
  • Author(s): Ohno N, Miyati T, Kasai H, Arai N, Kawano M, Shibamoto Y, Kobayashi S, Gabata T, Matsui O
  • Journal Title: Radiological Physics and Technology Volume: 8 Issue: 1 Pages: 135-140
  • DOI: 10.1007/s12194-014-0301-2
  • Peer Reviewed
• [Journal Article] Transfer characteristics of arterial pulsatile force in regional intracranial tissue using dynamic diffusion MRI: a phantom study (2014)
  • Author(s): Kan H
  • Journal Title: Magn Reson Imaging Volume: 32 Issue: 10 Pages: 1284-1289
  • DOI: 10.1016/j.mri.2014.08.026
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Gd-EOB-DTPA-enhanced magnetic resonance imaging and alpha-fetoprotein predict prognosis of early-stage hepatocellular carcinoma. (2014)
  • Author(s): Yamashita T, Kitao A, Matsui O, Hayashi T, Nio K, Kondo M, Ohno N, Miyati T, Okada H, Yamashita T, Mizukoshi E, Honda M, Nakanuma Y, Takamura H, Ohta T, Nakamoto Y, Yamamoto M, Takayama T, Arii S, Wang XW, Kaneko S
  • Journal Title: Hepatology Volume: in press Issue: 5 Pages: 1674-85
  • DOI: 10.1002/hep.27093
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of triexponential diffusion components in uterine cervical cancer (2014)
  • Author(s): 清水俊宏，宮地利明，大野直樹，小畠敏典，若山卓也
  • Journal Title: Medical Imaging and Information Sciences Volume: 31 Issue: 3 Pages: 54-59
  • DOI: 10.11318/mii.31.54
  • NAID: 130004700400
  • ISSN: 0910-1543, 1880-4977
  • Peer Reviewed
• [Journal Article] Diffusion Kurtosis in the Vertebral Bone Marrow (2014)
  • Author(s): 野田知寛，宮地利明，大野直樹，笠井治昌，荒井信行，依光理沙，川野誠，芝本雄太
  • Journal Title: Medical Imaging and Information Sciences Volume: 31 Issue: 1 Pages: 24-27
  • DOI: 10.11318/mii.31.24
  • NAID: 130003393069
  • ISSN: 0910-1543, 1880-4977
  • Peer Reviewed
• [Presentation] Verification of Dynamic ADC Change Due to Blood Flow using Cranial MRI-Phantom (2015)
  • Author(s): Ishida S, Miyati T, Ohno N, Hiratsuka S, Hiramatsu Y, Aoki T, Ono T, Gabata T
  • Organizer: 101st RSNA Meeting
  • Place of Presentation: シカゴ（USA）
  • Year and Date: 2015-11-29
  • Int'l Joint Research
• [Presentation] Function of the Lower-leg Using Simultaneous Acquisition of Transvers Relaxation, Perfusion, and Diffusion Information (2015)
  • Author(s): Terazono M, Miyati T, Ohno N, Fujihara S, Suzuki S, Koshino Y, Aoki T, Gabata T
  • Organizer: 101st RSNA Meeting
  • Place of Presentation: シカゴ（USA）
  • Year and Date: 2015-11-29
  • Int'l Joint Research
• [Presentation] Evaluation of Intracranial Condition in Head-down Tilt Posture using Magnetic Resonance Imaging (2015)
  • Author(s): Ishida S, Miyati T, Ohno N, Hiratsuka S, Alperin N, Kobayashi S, Yamamori R, Gabata T
  • Organizer: 101st RSNA Meeting
  • Place of Presentation: シカゴ（USA）
  • Year and Date: 2015-11-29
  • Int'l Joint Research
• [Presentation] Chemical-shift Displacement-based Simultaneous Water and Lipid Diffusion-EPI (2015)
  • Author(s): Aoki T, Miyati T, Kan H, Ohno N, Arai N, Ishida S, Ikeda S, Gabata T
  • Organizer: 101st RSNA Meeting
  • Place of Presentation: シカゴ（USA）
  • Year and Date: 2015-11-29
  • Int'l Joint Research
• [Presentation] Novel Practical SNR Determination Method for MRI Using Double Echo with Longest Second TE (2015)
  • Author(s): Niwa Y, Miyati T, Ohno N, Kan H, Ishida S, Kasai H, Tozawa T, Gabata T
  • Organizer: 101st RSNA Meeting
  • Place of Presentation: シカゴ（USA）
  • Year and Date: 2015-11-29
  • Int'l Joint Research
• [Presentation] Normal-Pressure Hydrocephalus: Temporal Changes in ADC during Cardiac Cycle (2015)
  • Author(s): Ohno N
  • Organizer: Picardie Jules Verne University Amiens University Hospital
  • Place of Presentation: アミアン（フランス）
  • Year and Date: 2015-09-15
  • Invited
• [Presentation] Influence of Blood Flow on Intracranial Water Fluctuation: A Phantom Study (2015)
  • Author(s): Ishida S, Miyati T, Ohno N, Chigusa T, Usui H, Hattori M, Hiramatsu Y, Kobayashi S, Gabata T
  • Organizer: ISMRM 23rd Annual Meeting & Exhibition
  • Place of Presentation: トロント（カナダ）
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] Simultaneous acquisition of transverse relaxation, perfusion, and diffusion information of lower-leg muscle using diffusion EPI with different TE (2015)
  • Author(s): Terazono M, Miyati T, Ohno N, Fujihara S, Makino N, Kobayashi S, Gabata T
  • Organizer: ISMRM 23rd Annual Meeting & Exhibition
  • Place of Presentation: トロント（カナダ）
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] IVIM in Brain using Novel Triexponential Analysis (2015)
  • Author(s): Ohno N, Miyati T, Kobayashi S, Gabata T, Matsui O
  • Organizer: 第71回日本放射線技術学会総会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-04-16
• [Presentation] Simultaneous Acquisition and Analysis of T2 and intravoxel incoherent motion of Lower-leg Muscle (2015)
  • Author(s): Terazono M，Miyati T, Ohno N, Fujihara S, Makino N
  • Organizer: 第71回日本放射線技術学会総会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-04-16
• [Presentation] Blood-flow Effect on Water Fluctuation in Brain Using Original Phantom (2015)
  • Author(s): Ishida S, Miyati T, Ohno N, Chigusa T, Usui H
  • Organizer: 第71回日本放射線技術学会総会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-04-16
• [Presentation] Novel Triexponential Analysis of Intravoxel Incoherent Motion for Brain Perfusion and Diffusion (2014)
  • Author(s): Ohno N, Miyati T, Kobayashi S, Gabata T, Matsui O
  • Organizer: 100th RSNA Meeting
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2014-11-30 – 2014-12-05
• [Presentation] Technical Aspects of Optimization for Gadoxetic Acid-enhanced Liver MR Imaging (2014)
  • Author(s): Kobayashi S, Ohno N, Fujinaga Y, Miyati T, Gabata T, Matsui O, Ikeno H, Koda W, Kozaka K, Inoue D, Yoshida K, Yoneda N, Minami T
  • Organizer: 100th RSNA Meeting
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2014-11-30 – 2014-12-05
• [Presentation] Integrated Phantom Analysis of Perfusion, Diffusion, and Fluctuation MRI (2014)
  • Author(s): Ohno N, Miyati T, Chigusa T, Usui H
  • Organizer: Joint Annual Meeting ISMRM-ESMRMB
  • Place of Presentation: Milan (Italy)
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Self Correction of Blood Flow Effect for Brain-Fluctuation MRI (2014)
  • Author(s): Takatsuji M, Miyati T, Ohno N, Yoshizawa S, Noda T, Kobayashi S, Gabata T, Matsui O
  • Organizer: Joint Annual Meeting ISMRM-ESMRMB
  • Place of Presentation: Milan (Italy)
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Development of cranial phantom for assessing intracranial condition (2014)
  • Author(s): 大野直樹，宮地利明，千種知紘，碓氷光
  • Organizer: 第70回日本放射線技術学会総会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-04-10 – 2014-04-13
• [Presentation] 下腿筋運動負荷時のbiexponential関数解析による拡散情報と血流および横緩和時間との関係 (2014)
  • Author(s): 寺園真，宮地利明，富士原修也，大野直樹
  • Organizer: 第70回日本放射線技術学会総会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-04-10 – 2014-04-13
• [Presentation] Restricted diffusion analysis using kurtosis imaging in the lumbar vertebral bone marrow (2014)
  • Author(s): 高辻麻里奈，宮地利明，野田知寛，大野直樹，笠井治昌，荒井信行，依光理沙
  • Organizer: 第70回日本放射線技術学会総会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-04-10 – 2014-04-13
• [Presentation] 脳揺動MRIにおける血流の影響の自己補正を目的とした心周期拡散解析 (2014)
  • Author(s): 高辻麻里奈，宮地利明，大野直樹，吉澤沙織，野田知寛
  • Organizer: 第70回日本放射線技術学会総会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-04-10 – 2014-04-13
• [Presentation] 特発性正常圧水頭症のタップテスト前後における頭蓋内髄液の水分子揺動解析 (2014)
  • Author(s): 平塚真之輔，宮地利明，大野直樹，中尾由利子，菅博人，笠井治昌，川野誠
  • Organizer: 第70回日本放射線技術学会総会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-04-10 – 2014-04-13
• [Presentation] 前立腺癌における拡散強調画像を用いたtriexponential解析 (2014)
  • Author(s): 上田優，高橋哲，大野直樹，川光秀昭，青山信和，宮地利明，奥秋知幸
  • Organizer: 第70回日本放射線技術学会総会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-04-10 – 2014-04-13
• [Presentation] Intravoxel incoherent motion (IVIM) in vertebral bone marrow (2014)
  • Author(s): Ohno N, Miyati T, Kasai H, Arai N, Kawano M, Shibamoto Y, Gabata T, Matsui O
  • Organizer: ECR 2014
  • Place of Presentation: Vienna (Austria)
• [Presentation] Cerebrospinal Fluid Fluctuation in the Ventricular System in Idiopathic Normal Pressure Hydrocephalus (2013)
  • Author(s): Ohno N, Miyati T, Mase M, Alperin N, Kasai H, Hiratsuka S, Kawano M, Shibamoto Y, Gabata T, Matsui O
  • Organizer: 99th RSNA
  • Place of Presentation: Chicago (USA)
• [Presentation] Development of Cranial MRI-Phantom for Assessing Perfusion, Diffusion, and Fluctuation (2013)
  • Author(s): Chigusa T, Miyati T, Ohno N, Usui H, Hiratsuka S, Kan H, Gabata T, Matusi O
  • Organizer: 99th RSNA
  • Place of Presentation: Chicago (USA)
• [Presentation] Water molecular fluctuation in ventricules and brain tissue in normal pressure hydrocephalus (2013)
  • Author(s): Mase M, Miyati T, Ohno N, Kan H, Kasai H, Yamada K
  • Organizer: Hydrocephalus 2013
  • Place of Presentation: Athens (Greece)
• [Presentation] 特発性正常圧水頭症における脳室のnormalizedΔADC解析 (2013)
  • Author(s): 大野直樹，宮地利明，間瀬光人，平塚真之輔，笠井治昌，荒井信行，川野誠
  • Organizer: 第69回日本放射線技術学会総会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Remarks] 金沢大学大学院医薬保健学総合研究科保健学専攻宮地研究室ホームページ
  • URL: http://miyatilab.w3.kanazawa-u.ac.jp
• [Remarks] 金沢大学大学院医薬保健学総合研究科保健学専攻宮地研究室ホームページ
  • URL: http://miyatilab.w3.kanazawa-u.ac.jp/index.htm
• [Remarks] 金沢大学大学院医薬保健学総合研究科保健学専攻宮地研究室ホームページ
  • URL: http://miyatilab.w3.kanazawa-u.ac.jp/index.htm