Biodistribution of omega-3 fatty acid in normal and aged rodents

• Project/Area Number: 25861077
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: INAKI Anri 金沢大学, 医学系, 助教 (40645131)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: ω-3脂肪酸 / 基礎的研究

Outline of Final Research Achievements

We assessed biodistribution of docosahexaenoic acid (DHA) in normal condition rat and amega-3 fatty acid deficiency rat. We administered C-14-radiolabelled DHA (1-[14C]-DHA) to 8-week-old normal rats and experimental rats which had been fed a non-ogega-3 fatty acid diet for 4 weeks, and then sacrificed them to investigate the biodistribution of 1-[14C]-DHA. In experimental groups, 1-[14C]-DHA uptake ratio of liver increased, and on the other hand, peak time of 1-[14C]-DHA uptake was delayed, compared with control groups.