Anticancer therapy controlling vascular permeability in interventional radiology

• Project/Area Number: 25861078
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: Yoshida Kotaro 金沢大学, 医学系, 助教 (30645130)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 血管透過性 / permeability / IVR / バリアー機能 / 血管内皮 / 経血管インターベンション / 薬剤輸送システム / 血管バリアー機能

Outline of Final Research Achievements

In this project, we obtained the protocol of noninvasive intravascular interventional approach from femoral artery and catheterization to selective hepatic arteries. In steady condition, there is no sign of extravasation of FITC-dextran injected from hepatic artery. And there is no sign of extravasation of FITX-dextran in the drug administration model of nitroglycerin, sodium nitroprusside, histamine, and platelet activating factor. On the other hand, in liver VX-2 tumor model, the hyper-vascular permeability was observed at the peritumoral area in administration of nitroglycerin.