|Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|Outline of Final Research Achievements
In this project, we obtained the protocol of noninvasive intravascular interventional approach from femoral artery and catheterization to selective hepatic arteries. In steady condition, there is no sign of extravasation of FITC-dextran injected from hepatic artery. And there is no sign of extravasation of FITX-dextran in the drug administration model of nitroglycerin, sodium nitroprusside, histamine, and platelet activating factor. On the other hand, in liver VX-2 tumor model, the hyper-vascular permeability was observed at the peritumoral area in administration of nitroglycerin.