Kinetic analysis of Estrogen receptpr PET imaging in gynecological tumors

Research Project

Project/Area Number	25861079
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Radiation science
Research Institution	University of Fukui
Principal Investigator	TSUJIKAWA Tetsuya 福井大学, 高エネルギー医学研究センター, 准教授 (30380033)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	エストロゲン受容体PET / 動態解析 / 婦人科腫瘍 / ダイナミックPET / エストロゲン受容体 / PET
Outline of Final Research Achievements	Dynamic PET scan with 16α-[18F]fluoro-17β-estradiol (FES) was performed in patients with huge uterine leiomyoma. Rate constants (K1, k2, k3, k4), volume of distribution (VT) and k3/k4 (Binding potential) were obtained by 2-tissue compartmental modeling. They were compared with standardized uptake values at the time of 60 min after tracer injection. Binding potential and VT showed significantly positive correlations with SUV. This result indicates that FES PET kinetic analysis is feasible in gynecological tumors and that SUV is properly-validated.

Report

(3 results)