Kinetic analysis of Estrogen receptpr PET imaging in gynecological tumors
| Project/Area Number |
25861079
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | University of Fukui |
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Principal Investigator |
TSUJIKAWA Tetsuya 福井大学, 高エネルギー医学研究センター, 准教授 (30380033)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | エストロゲン受容体PET / 動態解析 / 婦人科腫瘍 / ダイナミックPET / エストロゲン受容体 / PET |
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| Outline of Final Research Achievements |
Dynamic PET scan with 16α-[18F]fluoro-17β-estradiol (FES) was performed in patients with huge uterine leiomyoma. Rate constants (K1, k2, k3, k4), volume of distribution (VT) and k3/k4 (Binding potential) were obtained by 2-tissue compartmental modeling. They were compared with standardized uptake values at the time of 60 min after tracer injection. Binding potential and VT showed significantly positive correlations with SUV. This result indicates that FES PET kinetic analysis is feasible in gynecological tumors and that SUV is properly-validated.
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Report
(3 results)
Research Products
(2 results)
