Elucidation of mechanisms for tumor malignancy and radioresistance by crosstalk between Hypoxia, circadian rhythm and metabolic regulation
| Project/Area Number |
25861088
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
KOBAYASHI minoru 京都大学, 医学(系)研究科(研究院), 特定研究員 (40644894)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 低酸素 / 概日リズム / 放射線抵抗性 |
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| Outline of Final Research Achievements |
Previously, crosstalk between circadian rhythm and hypoxia response were reported but this mechanism is unclear. So, we analyzed mechanisms of crosstalk between PER2 which is one of circadian regulated genes, and hypoxia response. Then we revealed that the short sequence near transcription start site is important for PER2 gene upregulation by hypoxia but Hypoxia-Inducible Factor (HIF) does not contribute to this regulation. And we found that PER2 protein N-terminal region enhance transactivation activity from HIF-1 C-terminal transactivation domain.
In future, by clarify the mechanisms of crosstalk between circadian rhythm and hypoxia responses, we expect unraveling of physiological and pathophysiological significance in this crosstalk.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1alpha2015
Author(s)
Goto Y, Zeng L, YeomCJ, Zhu Y, Morinibu A, Shinoyam K, Kobayashi M, Hirota K, Itasaka S, Yoshimura M, Tanimoto K, Sowa T, Menju T, Sonobe M, Kakeya H, Toi M, Date H, Hammond EM, Hiraoka M, Harada H.
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Journal Title
Nat Commun
Volume: 6
Issue: 1
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis.2014
Author(s)
Zeng L, Morinibu A, Kobayashi M, Zhu Y, Wang X, Goto Y, Yeom CJ, Zhao T,Hirota K, Shinomiya K, Itasaka S, Yoshimura M, Guo G, Hammond EM, Hiraoka M, Harada H.
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Journal Title
Oncogene
Volume: epub
Issue: 36
Pages: 4758-4766
DOI
Related Report
Peer Reviewed / Open Access
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