| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Outline of Final Research Achievements |
Assessment of muscle blood flow response (MFR) by dynamic muscle blood oxygen level-dependent (BOLD) magnetic resonance (MR) imaging is unknown. First, we developed the method to assess BOLD effect in the muscle by using 3 tesla MR and performed its validation with a new developed in-house software. Second, we investigated the effect of smoking on vascular function according to MFR during postocclusive reactive hyperemia in young smokers and nonsmokers. We underwent BOLD imaging in sixteen healthy male volunteers. The 2 key mBOLD variables such as times to half hyperemic peak (T1/2peak) and times to peak (TTP) were evaluated. This study showed that T1/2peak and TTP were significantly longer in smokers in reactive hyperemia. Dynamic BOLD MR imaging of calf muscle during postocclusive reactive hyperemia demonstrated statistically significant differences in T1/2peak and TTP between young smokers and nonsmokers, indicating the presence of early stage smoking-related deterioration in MFR.
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