Research on new biomarker of radiotresistance in HPV associated head and neck cancer
Project/Area Number |
25861103
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Radiation science
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Research Institution | Kobe University |
Principal Investigator |
MIYAWAKI DAISUKE 神戸大学, 医学(系)研究科(研究院), 助教 (30546502)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 放射線腫瘍学 / 放射線抵抗性 / 放射線治療 / 中咽頭癌 / HPV |
Outline of Final Research Achievements |
The purpose of this study was to evaluate nuclear factor-kappaB (NF-KappaB) as a marker of radioresistance in oropharyngeal carcinomas. Immunohistochemistry was performed using pretreatment biopsy specimen to evaluate the presence of NF-kappaB expression in these tumor. Similar experiments was performed in subgroups of recurrent tumor specimens. The prognostic value of other molecular markers such as Bcl-2 and epidermal growth factor (EGF) receptor were also evaluated and compared with NF-kappaB. NF-kappaB expression in pretreatment tumors correlated with local tumor control. NF-kappaB expression may be a novel marker of radioresistance in oropharyngeal carcinomas. Bcl-2 and EGF receptor expression did not correlate with radioresistance.
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Report
(3 results)
Research Products
(62 results)
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[Journal Article] Prognostic Value of FDG PET Imaging in Patients with Laryngeal Cancer2014
Author(s)
Kitajima K, Suenaga Y, Kanda T, Miyawaki D, Yoshida K, Ejima Y, Sasaki R, Komatsu H, Saito M, Otsuki N, Nibu K, Kiyota N, Minamikawa T, Sugimura K.
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Journal Title
PLoS One
Volume: 9(5)
Issue: 5
Pages: e96999-e96999
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] 頭頸部癌に対するセツキシマブ併用放射線治療の初期経験2014
Author(s)
上薗 玄, 江島 泰生, 宮脇 大輔, 四宮 弘隆, 小松 弘和, 藤尾 久美, 森本 浩一, 今村 善宣, 斉藤 幹, 大月 直樹, 清田 尚臣, 佐々木 良平, 丹生 健一
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Journal Title
頭頸部癌
Volume: 40
Pages: 265-265
Related Report
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[Journal Article] 中咽頭癌に対する化学放射線療法におけるPEG留置患者の栄養投与量と有害事象2014
Author(s)
高橋 美貴, 小坂 奈々, 宇佐美 眞, 中川 絵美, 齋藤 幹, 大月 直樹, 江島 泰生, 宮脇 大輔, 佐々木 良平, 清田 尚臣, 丹生 健一
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Journal Title
頭頸部癌
Volume: 40
Pages: 238-238
Related Report
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[Journal Article] T3N0-1声門癌に対する喉頭温存を目的とした根治的化学放射線治療の検討2014
Author(s)
佐々木 良平, 松尾 圭朗, 江島 泰生, 宮脇 大輔, 上薗 玄, 今村 善宣, 清田 尚臣, 四宮 弘隆, 小松 弘和, 森本 浩一, 斉藤 幹, 大月 直樹, 丹生 健一
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Journal Title
頭頸部癌
Volume: 40
Pages: 155-155
Related Report
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[Journal Article] 過酸化チタンナノ粒子による放射線増感の検討2014
Author(s)
中山 雅央, 佐々木 良平, 西村 英輝, 吉田 賢史, 宮脇 大輔, 赤坂 浩亮, 椋本 成俊, 村岡 修, 原田 文, ノルシャズリナ , 上原 和之, 田中 勉, 荻野 千秋, 近藤 昭彦
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Journal Title
Japanese Journal of Radiology
Volume: 32
Pages: 37-37
Related Report
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[Journal Article] 喉頭原発悪性リンパ腫に対する放射線治療の経験2014
Author(s)
井上 由子, 吉田 賢史, 宮脇 大輔, 西村 英輝, 原田 文, 村岡 修, ノル・シャズリナ , 佐々木 良平, 岡村 篤夫, 斎藤 幹, 丹生 健一
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Journal Title
Japanese Journal of Radiology
Volume: 32
Pages: 36-36
Related Report
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[Presentation] Efficacy of PGA Spacer in Particle Therapy: A novel strategy Making Temporal Space between Tumor and Adjacent Organs2014
Author(s)
H Akasaka, R Sasaki, D Miyawaki, N Mukumoto, NS Sulaiman, TY Wang, S Yamada, M Murakami, Y Demizu, T Fukumoto
Organizer
MMND & IPCT 2014
Place of Presentation
Port Douglas, Australia
Year and Date
2014-10-20 – 2014-10-25
Related Report
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[Presentation] A Novel Radiosensitizer, Monogalactosyl diacylglycerol, Enhanced the Cytotoxic Effects for the Pancreatic Cancer2014
Author(s)
H Akasaka, R Sasaki, I Takayama, M Nakahana, NS Sulaiman, D Miyawaki, K Yoshida, Y Ejima, H Uezono, Y Mizushina
Organizer
The 15th Asian Oceanian Congress of Radiology
Place of Presentation
Kobe
Year and Date
2014-09-24 – 2014-09-28
Related Report
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[Presentation] Assessment of Correlation and Prediction Errors of the CyberKnife Synchrony Respiratory Tracking Ststem for the Treatment of Liver Tumors2014
Author(s)
M Nakayama, T Ogata, K Uehara, H Nishimura, H Mayahara, A Harada, Y Matsuo, Y Ejima, D Miyawaki, R Sasaki, J Ishida , M Fujii
Organizer
The 15th Asian Oceanian Congress of Radiology
Place of Presentation
Kobe
Year and Date
2014-09-24 – 2014-09-28
Related Report
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[Presentation] Retrospective analysis of whole brain radiotherapy for brain metastases2014
Author(s)
H Uezono, Y Ejima, D Miyawaki, T Ishihara, Y Imamura, H Shinomiya, H Komatsu, H Fujio, K Morimoto, M Saito, N Otsuki, N Kiyota, R Sasaki, K Nibu
Organizer
The 15th Asian Oceanian Congress of Radiology
Place of Presentation
Kobe
Year and Date
2014-09-24 – 2014-09-28
Related Report
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[Presentation] Experience of radiotherapy plus cetuximab for head and neck cancer2014
Author(s)
H Uezono, Y Ejima, D Miyawaki, T Ishihara, Y Imamura, H Shinomiya, H Komatsu, H Fujio, K Morimoto, M Saito, N Otsuki, N Kiyota, R Sasaki, K Nibu
Organizer
The 15th Asian Oceanian Congress of Radiology
Place of Presentation
Kobe
Year and Date
2014-09-24 – 2014-09-28
Related Report
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[Presentation] A Novel Radiosensitizer, Monogalactosyl diacylglycerol, Enhanced the Cytotoxic Effects for the Pancreatic Cancer2014
Author(s)
H Akasaka, R Sasaki, I Takayama, M Nakahana, NS Sulaiman, D Miyawaki, K Yoshida, Y Ejima, H Uezono, Y Mizushina
Organizer
European Society for Radiotherapy & Oncology 33
Place of Presentation
Vienna
Year and Date
2014-04-04 – 2014-04-08
Related Report
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[Presentation] "Impact of Symptom Rescue by Fractionated Radiotherapy for Rare Angiogenetic Neoplasm of the Abdomen, Vertebra, and Head and Neck Regions "2013
Author(s)
Y Matsuo, K Yoshida, D Miyawaki, Y Ejima, Nor Shazrina Sulaiman, Y Kojima, M Yamaguchi, K Sugimoto, R Sasaki
Organizer
55th Annual meeting ASTRO
Place of Presentation
Atlanta
Related Report
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[Presentation] A Novel Radiosensitizor of the Functional Food Component, Monogalactosyl diacylglycerol (MGDG) from Spinach, Enhanced the Cytotoxic Effects for the Pancreatic Cancer In Vitro and In Vivo2013
Author(s)
H. Akasaka, R. Sasaki, N. Mukumoto, M. Nakayama, N.S. Sulaiman, D. Miyawaki, K. Yoshida, Y. Ejima, Y. Mizushina
Organizer
55th Annual meeting ASTRO
Place of Presentation
Atlanta
Related Report
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