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Cryoablation of venous malformations; prospective safety confirmation study.

Research Project

Project/Area Number 25861106
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionOkayama University

Principal Investigator

Fujiwara Hiroyasu  岡山大学, 大学病院, 講師 (70423324)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsCryoablation / 凍結療法 / venous malformation / 静脈奇形 / hemangioma / 血管腫 / 疼痛 / VAS / 血管奇形 / 凍結
Outline of Final Research Achievements

Cryoablation for vascular malformations were performed as a prospective safety confirmation test. 9 patients were enrolled in this study as scheduled on protocol. All patients had venous malformation, one had in pelvis and another 8 had in lower extremity. All lesions were successfully treated by cryoablation under local anesthesia without severe complications. Post treatment swelling or pain were occurred but improved conservatively.
The therapeutic outcome was satisfactory and all patients showed remarkable improvement of the local pain and lesion decrease. VAS score decreased from 6.3 to 2.5 at one month, 0.4 at 3 months in an average. The volume reduction was also obtained in all patients. 6 lesions, which were small limited venous malformations and treated entirely, were almost disappeared on MRI.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (21 results)

All 2017 2016 2015 2013

All Journal Article (13 results) (of which Peer Reviewed: 12 results) Presentation (8 results) (of which Invited: 1 results)

  • [Journal Article] Radiofrequency ablation of pulmonary metastases from sarcoma: single-center retrospective evaluation of 46 patients.2017

    • Author(s)
      Sato T, Iguchi T, Hiraki T, Gobara H, Fujiwara H, Sakurai J, Matsui Y, Mitsuhashi T, Soh J, Toyooka S,, Kanazawa S.
    • Journal Title

      Jpn J Radiol.

      Volume: 35 Issue: 2 Pages: 61-67

    • DOI

      10.1007/s11604-016-0601-z

    • NAID

      210000178566

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Lung Radiofrequency Ablation With Dual-Energy Computed Tomography: Analysis of Tumor Composition and Lung Perfusion.2016

    • Author(s)
      Tomita K, Hiraki T, Gobara H, Fujiwara H, Iguchi T, Matsui Y, Kanazawa S.
    • Journal Title

      J Comput Assist Tomogr.

      Volume: 40 Issue: 5 Pages: 752-756

    • DOI

      10.1097/rct.0000000000000422

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous biopsy and radiofrequency ablation of T1a renal cell carcinoma.2016

    • Author(s)
      Iguchi T, Hiraki T, Tomita K, Gobara H, Fujiwara H, Sakurai J, Matsui Y, Kanazawa S.
    • Journal Title

      Diagn Interv Imaging.

      Volume: 97 Issue: 11 Pages: 1159-1164

    • DOI

      10.1016/j.diii.2016.05.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Computed Tomography-guided Radiofrequency Ablation for Sub-diaphragm Hepatocellular Carcinoma: Safety and Effcacy of Inducing an Articial Pneumothorax2016

    • Author(s)
      Fujiwara H, Arai Y, Ishii H, Kanazawa S
    • Journal Title

      Acta Med Okayama.

      Volume: 70 Pages: 189-195

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Safety of Percutaneous Cryoablation in Patients with Painful Bone and Soft Tissue Tumors: A Single Center Prospective Study (SCIRO-1502)2016

    • Author(s)
      Iguchi T, Sakurai J, Hiraki T, Gobara H, Fujiwara H, Matsui Y, Masaoka Y, Kanazawa S
    • Journal Title

      Acta Medica Okayama

      Volume: 70 Pages: 303-306

    • NAID

      120005828921

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single Center Prospective Phase ⅡTrial of CT-guided Radiofrequency Ablation for Pulmonary Metastases from Colorectal Cancer (SCIRO-1401)2016

    • Author(s)
      Sakurai J, Matsui Y, Hiraki T, Iguchi T, Fujiwara H, Gobara H, Mitsuhashi T, Nagasaka T, Kanazawa S
    • Journal Title

      Acta Medica Okayama

      Volume: 70 Pages: 317-321

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fracture of totally implanted central venous access devices: a propensity-score-matched comparison of risks for Groshong silicone versus polyurethane catheters.2016

    • Author(s)
      Kojima S, Hiraki T, Gobara H, Iguchi T, Fujiwara H, Matsui Y, Mitsuhashi T, Kanazawa S.
    • Journal Title

      J Vasc Access.

      Volume: 17 Issue: 6 Pages: 535-541

    • DOI

      10.5301/jva.5000606

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Percutaneous CT-guided Radiofrequency Ablation for Renal Cell Carcinoma in von Hippel-Lindau Disease:Midterm Results.2016

    • Author(s)
      Gobara H, Hiraki T, Iguchi T, Fujiwara H, Nasu Y, Kanazawa S
    • Journal Title

      Interventional Radiology

      Volume: 1 Pages: 1-6

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 【IVR治療戦略:術前に必要な画像診断はこれだ!】軟部血管奇形のIVRに必要な画像診断の実際(解説/特集).2015

    • Author(s)
      三村秀文, 小川普久, 荒井保典, 橋本一樹, 濱口真吾, 中島康雄, 芝本健太郎, 宗田由子, 加藤勝也, 藤原寛康, 金澤右.
    • Journal Title

      臨床画像

      Volume: 31 Pages: 618-626

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lung Cancer Ablation: Complications.2013

    • Author(s)
      Takao Hiraki, Hideo Gobara, Hiroyasu Fujiwara, Hiroaki Ishii, Koji Tomita, Mayu Uka, Satoko Makimoto, Susumu Kanazawa
    • Journal Title

      Semin intervent Radiol.

      Volume: 30 Pages: 169-175

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] アブレーション:腎癌 -凍結療法を中心に-2013

    • Author(s)
      郷原英夫、平木隆夫、藤原寛康、生口俊浩、松井裕輔、金澤 右
    • Journal Title

      臨床画像

      Volume: 29 Pages: 880-885

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oligometastastases,oligo-recurrenceヘのRFAの応用2013

    • Author(s)
      平木隆夫、郷原英夫、生口俊浩、藤原寛康、松井裕輔、金澤 右
    • Journal Title

      臨床放射線

      Volume: 58 Pages: 1069-1075

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Radiofrequency ablation as treatment for pulmonary metastasis of colorectal cancer2013

    • Author(s)
      Takao Hiraki, Hideo Gobara, Toshihiro Iguchi, Hiroyasu Fujiwara, Yusuke Matsui, Susumu Kanazawa
    • Journal Title

      World J Gastroenterol

      Volume: 20 Issue: 4 Pages: 988-996

    • DOI

      10.3748/wjg.v20.i4.988

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Cryotherapy for venous malformation.2016

    • Author(s)
      Fujiwara H
    • Organizer
      第43回 日本低温医学会総会
    • Place of Presentation
      国立スポーツ科学センター
    • Year and Date
      2016-10-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 前腕静脈奇形に対して凍結療法を施行した1例2016

    • Author(s)
      藤原寛康、郷原英夫、平木隆夫、生口俊浩、櫻井 淳、馬越紀行、梶田聡一郎、小牧稔幸、金澤 右
    • Organizer
      第45回 日本IVR学会総会
    • Place of Presentation
      ウェスティンナゴヤキャッスル
    • Year and Date
      2016-05-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 腎・骨軟部凍結療法2016

    • Author(s)
      藤原寛康
    • Organizer
      第75回 日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 静脈奇形に対する凍結療法後のMRI所見に関する検討2016

    • Author(s)
      藤原寛康
    • Organizer
      第75回 日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 肝移植後にトリコアキシシャルシステムを使用してPSEを施行した2例2015

    • Author(s)
      藤原寛康
    • Organizer
      第125回日本医学放射線学会中国・四国地方会
    • Place of Presentation
      高知城ホール
    • Year and Date
      2015-12-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 静脈奇形に対する凍結療法2015

    • Author(s)
      藤原寛康
    • Organizer
      第35回日本静脈学会
    • Place of Presentation
      奈良市
    • Year and Date
      2015-07-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 良性胆管狭窄に対するチューブステント留置の長期成績2013

    • Author(s)
      藤原寛康、石井裕朗、平木隆夫、郷原英夫、金澤 右、三村 秀文
    • Organizer
      第72回 日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 腎癌に対する凍結療法:初期経験の報告2013

    • Author(s)
      藤原寛康、平木隆夫、淀谷光子、小河七子、槇本怜子、宇賀麻由、冨田晃司、石井裕朗、郷原英夫、金澤 右
    • Organizer
      第42回 日本IVR学会総会
    • Place of Presentation
      軽井沢プリンスホテル
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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