A novel, non-invasive, MRI based approach to the measurement of OEF, CBF and CMRO2 in the human brain.
| Project/Area Number |
25861120
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Research Collaborator |
PARKES Laura University of Manchester
KUDO Kohsuke 北海道大学
SASAKI Makoto 岩手医科大学
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | SWI / OEF / CBF / ASL / multi-banding / CMRO2 / Look Locker / Multi Banding / 7T / 3T / O2 |
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| Outline of Final Research Achievements |
OEF post processing techniques were demonstrated in a healthy population during concious sedation (Goodwin et al 2014). Subsequent work focused on development of CBF measurement using ASL MRI; necessary for developing a combined imaging approach to CMRO2 measurement. However, there were several technical limitations. Initial efforts focused on ASL using 7T MRI, but it became apparent that this approach was no longer available option with our current 7T system. Instead, collaborative work commenced on development of 3T ASL with multi-banding and Look Locker readout. This involved 6 months in the University of Manchester, UK. If successful, this technique would increase brain coverage allow CBF arrival time measurement. A number of experiments were carried out to try and establish this method, in collaboration with Philips engineers, and a number of technical challenges were discovered, which ultimately were not resolved prior to the end of the Kakenhi period. This research is ongoing.
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Report
(3 results)
Research Products
(2 results)
