| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
A novel estimation method which allows PET acquisition after administration certain time without the arterial blood sampling was proposed in this study.
The proposed method is a kind of graphical analysis such as Logan plot, constructed a new model represented a tissue time-activity curve after a certain time from drag administration by a linear sum of three exponential function. Moreover, the rate constants were estimated by Laguerre polynomial approximation, and then calculated the total volume of distribution and receptor binding potential.
The proposed method was sensitive noise of image, and estimated variance was significantly greater compared with other estimation methods.
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