White matter changes in patients with metabolic syndrome by diffusion tensor imaging analysis and diffusional kurtosis imaging analysis.

• Project/Area Number: 25861126
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2014); 独立行政法人国立精神・神経医療研究センター (2013)
• Principal Investigator: KEIGO Shimoji 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (20348931)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: MRI / brain / diffusion tensor imaging / diffusional kurtosis / metabolic syndrome / brain magnetic resonance / diffusion tensor

Outline of Final Research Achievements

Our research suggests that microstructural white matter changes occur in middle-aged men with hypertension, even before the onset of cerebrovascular disease.
Our research also suggests that microstructural white matter changes occur in patients with metabolic syndrome. The fractional anisotropy values may be useful indices of white matter alterations in patients with metabolic syndrome.

Research Products

• [Journal Article] 【神経放射線診断Update "Knowledge is power"】 白質の解剖 (2015)
  • Author(s): 下地啓五
  • Journal Title: 画像診断 Volume: 35(4)
• [Journal Article] Diffusional kurtosis imaging analysis in patients with hypertension. (2014)
  • Author(s): Shimoji K, Uka T, Tamura Y, Yoshida M, Kamagata K, Hori M, Motoi Y, Watada H, Kawamori R, Aoki S
  • Journal Title: Jpn J Radiol Volume: 32 Issue: 2 Pages: 98-104
  • DOI: 10.1007/s11604-013-0275-8
  • NAID: 50008937000
  • Peer Reviewed
• [Journal Article] A preliminary diffusional kurtosis imaging study of Parkinson disease: comparison with conventional diffusion tensor imaging. (2014)
  • Author(s): Kamagata K, Tomiyama H, Hatano T, Motoi Y, Abe O, Shimoji K, Kamiya K, Suzuki M, Hori M, Yoshida M, Hattori N, Aoki S.
  • Journal Title: Neuroradiology Volume: 56 Issue: 3 Pages: 251-258
  • DOI: 10.1007/s00234-014-1327-1
  • Peer Reviewed
• [Journal Article] Anterior cingulate abnormality as a neural correlate of mismatch negativity in schizophrenia (2013)
  • Author(s): Hayakawa Y, Kirino E, Shimoji K, Kamagata K, Hori M, Ito K, Kunimatsu A, Abe O, Ohtomo K, Aoki S
  • Journal Title: Neuropsychobioloy Volume: 68(4) Issue: 4 Pages: 197-204
  • DOI: 10.1159/000355296
  • Peer Reviewed
• [Journal Article] Diffusional kurtosis imaging of cingulate fibers in Parkinson disease: comparison with conventional diffusion tensor imaging. (2013)
  • Author(s): Kamagata K
  • Journal Title: Magn Reson Imaging. Volume: 31(9) Issue: 9 Pages: 1501-1506
  • DOI: 10.1016/j.mri.2013.06.009
  • Peer Reviewed
• [Journal Article] Consecutive acquisition of time-resolved contrast-enhanced MR angiography and perfusion MR imaging with added dose of gadolinium-based contrast agent aids diagnosis of suspected brain metastasis. (2013)
  • Author(s): Tsuchiya K, Aoki S, Shimoji K, Mori H, Kunimatsu A.
  • Journal Title: Magn Reson Med Sci. Volume: 12(2) Pages: 87-93
  • NAID: 10031183921
  • Peer Reviewed
• [Journal Article] Effects of diffusional kurtosis imaging parameters on diffusion quantification (2013)
  • Author(s): Fukunaga I, Hori M, Masutani Y, Hamasaki N, Sato S, Suzuki Y, Kumagai F, Kosuge M, Hoshito H, Kamagata K, Shimoji K, Nakanishi A, Aoki S, Senoo A.
  • Journal Title: Radiol Phys Technol Volume: 6 Issue: 2 Pages: 343-348
  • DOI: 10.1007/s12194-013-0206-5
  • Peer Reviewed
• [Journal Article] Relationship between cognitive impairment and white-matter alteration in Parkinson’s disease with dementia: tract-based spatial statistics and tract-specific analysis. (2013)
  • Author(s): Kamagata K
  • Journal Title: Eur Radiol. Volume: 23(7) Issue: 7 Pages: 1946-1955
  • DOI: 10.1007/s00330-013-2775-4
  • Peer Reviewed
• [Presentation] 神経放射線Update 教科書にはない白質の解剖 (2015)
  • Author(s): 下地啓五
  • Organizer: 日本医学放射線学会関東地方会セミナー
  • Place of Presentation: 東京 丸の内マイプラザ
  • Invited
• [Presentation] シンポジウム 多施設評価のためのMR定量化と統計解析-拡散テンソル像- (2014)
  • Author(s): 下地啓五、佐藤典子、青木茂樹
  • Organizer: 第41回日本磁気共鳴医学会大会
  • Place of Presentation: 徳島市 アスティ徳島１階多目的ホール
  • Invited
• [Presentation] シンポジウム 脳高次機能障害の診断と治療への貢献 拡散テンソルを用いた高次脳機能障害の評価
  • Author(s): 下地啓五
  • Organizer: 第37回日本脳神経CI学会総会
  • Place of Presentation: さいたま市大宮ソニックシティA会場
  • Invited
• [Presentation] DTI中級編
  • Author(s): 下地啓五
  • Organizer: 包括脳 正常拠点―疾患拠点合同MRIチュートリアル
  • Place of Presentation: 東京大学医学部附属病院大会議室
  • Invited
• [Presentation] DTI初級編
  • Author(s): 下地啓五
  • Organizer: 包括脳 正常拠点―疾患拠点合同MRIチュートリアル
  • Place of Presentation: 東京大学医学部附属病院大会議室
  • Invited
• [Book] これでわかる拡散ＭＲＩ 第3版 (2013)
  • Author(s): 青木茂樹, 増谷佳孝, 高原太郎, 阿部 修（編著）
  • Total Pages: 488
  • Publisher: 学研メディカル秀潤社