| Project/Area Number |
25861129
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Tokai University (2015)
Nippon Medical School (2013-2014) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 放射線医学 / 血管内治療 / 肝細胞がん / 肝動脈化学塞栓術 / リピオドール / NBCA / 油性造影剤 / 液状塞栓物質 / IVR / 塞栓術 / 粘稠度 / n-butyl cyanoacrylate / 冠動脈化学塞栓術 |
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| Outline of Final Research Achievements |
As in vitro study, we evaluated the influence of temperature on the viscosity of mixtures with different NBCA-Lipiodol concentration. In the result, warming of the mixture decreases the viscosity and the higher concentration of NBCA within the mixture make the viscosity lower.
As in vivo study, we performed transcatheter arterial embolization of renal arteries of rabbits using NBCA-Lipiodol mixtures with various temperatures (3, 20 and 50 degrees) and concentrations (50, 33, 25 % of NBCA). Then, the difference of the distribution of NBCA-Lipiodol mixture within the renal artery was histopathologically evaluated using Oil Red staining. In the result, the mixture with the lower viscosity tends to distribute in the renal arteries with the smaller diameters.
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