Control of viscosity of Lipiodol and development of low-viscosity oily contrast media
| Project/Area Number |
25861129
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Tokai University (2015)
Nippon Medical School (2013-2014) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 放射線医学 / 血管内治療 / 肝細胞がん / 肝動脈化学塞栓術 / リピオドール / NBCA / 油性造影剤 / 液状塞栓物質 / IVR / 塞栓術 / 粘稠度 / n-butyl cyanoacrylate / 冠動脈化学塞栓術 |
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| Outline of Final Research Achievements |
As in vitro study, we evaluated the influence of temperature on the viscosity of mixtures with different NBCA-Lipiodol concentration. In the result, warming of the mixture decreases the viscosity and the higher concentration of NBCA within the mixture make the viscosity lower.
As in vivo study, we performed transcatheter arterial embolization of renal arteries of rabbits using NBCA-Lipiodol mixtures with various temperatures (3, 20 and 50 degrees) and concentrations (50, 33, 25 % of NBCA). Then, the difference of the distribution of NBCA-Lipiodol mixture within the renal artery was histopathologically evaluated using Oil Red staining. In the result, the mixture with the lower viscosity tends to distribute in the renal arteries with the smaller diameters.
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Report
(4 results)
Research Products
(56 results)
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Author(s)
長谷部光泉, 松本知博, 嶺 貴彦，堀田 篤, 鈴木哲也
Organizer
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Place of Presentation
西武信用金庫八王子支店 2階会議室（東京都八王子市）
Year and Date
2015-12-02
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松本知博，嶺貴彦，長谷部光泉
Organizer
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2015-11-17
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Organizer
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Place of Presentation
パシフィコ横浜（神奈川県横浜市）
Year and Date
2015-09-10
Related Report
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Author(s)
松本知博，嶺貴彦，長谷部光泉
Organizer
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Place of Presentation
ホテル ザ・エルシィ町田（東京都町田市）
Year and Date
2015-08-29
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Organizer
The 9th International Conference on New Diamond and Nano Carbons 2015 (NDNC2015)
Place of Presentation
静岡グランシップ（静岡県静岡市）
Year and Date
2015-05-27
Related Report
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Place of Presentation
Turk, Finland
Year and Date
2014-06-11 – 2014-06-13
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Author(s)
嶺貴彦,村田智,中澤賢,小野澤志郎,上田達夫,山口英宣,杉原史恵,秋葉絢子,安井大祐,三樹いずみ,會田久美子,川俣博志,進藤惠美,田島廣之,汲田伸一郎
Organizer
第42回日本IVR学会総会
Place of Presentation
軽井沢
Related Report
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