Retrograde-outflow isolated hepatic perfusion therapy for hepatic tumor
| Project/Area Number |
25861130
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Nippon Medical School |
|---|
Principal Investigator |
ONOZAWA Shiro 日本医科大学, 医学部, 助教 (10544398)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | ドラッグデリバリーシステム / 肝灌流療法 / IVR / シスプラチン / VX2担がんウサギ / ドラッグテリバリーシステム |
|---|
| Outline of Final Research Achievements |
We performed retrograde-outflow isolated hepatic perfusion circuit in normal rabbit and implantation of VX2 tumor for rabbit liver. The rabbit hepatic isolated perfusion circuit required the open laparotomy to cannulate the portal vein instead of percutaneous access because of the small rabbit liver and portal vein. On the other hand, it was not easy to create the rabbit VX2 liver tumor model because of the dissemination of the tumor and adhesion due to tumor and surgical intervention. In particular, creating the isolated hepatic circuit in the VX2 tumor model was the biggest issue because the adhesion after VX2 implantation interfered with portal venous cannulation. However the know-how to create the isolated hepatic circuit and of VX2 implantation were very important to advance the research further more.
|
Report
(3 results)
Research Products
(20 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 臓器虚血が出現したStanford B型急性大動脈解離に対し経皮的腹部大動脈開窓術を施行した一例
Author(s)
三樹いずみ, 村田智, 小野澤志郎, 中澤賢, 嶺貴彦, 上田達夫, 山口英宜, 杉原史恵, 秋葉絢子, 安井大祐, 汲田伸一郎
Organizer
第42回日本IVR学会総会
Place of Presentation
軽井沢
Related Report
-
-
-
-
-
