Is balance of metabotropic glutamate receptors classified into group I important?

• Project/Area Number: 25861135
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: Yamasaki Tomoteru 国立研究開発法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (80627563)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: PET / mGluR1 / mGluR5 / パーキンソン病 / ドーパミン / α-シヌクレイン / 代謝型グルタミン酸受容体 / ドーパミントランスポーター / DAT / Open-Field Test

Outline of Final Research Achievements

In this study, dynamic changes of metabotropic glutamate receptors (mGluR1 and mGluR5) classified into group I were monitored by using longitudinal positron emission tomography (PET) in Parkinson's disease (PD) modeled animal. PET imaging demonstrated that mGluR1 expressions, but not mGluR5, dynamically changed with progression of PD pathology. Hence, it was suggested that mGluR1 might be a new biomarker for diagnostic index of PD.

Research Products

• [Journal Article] Dynamic changes in striatal mGluR1 but not mGluR5 during pathological progression of Parkinson's Disease in human alpha-synuclein A53T transgenic rats: A multi-PET imaging study (2016)
  • Author(s): Yamasaki T, Fujinaga M, Kawamura K, Furutsuka K, Nengaki N, Shimoda Y, Shiomi S, Takei M, Hashimoto H, Yui J, Wakizaka H, Hatori A, Xie L, Kumata K, Zhang MR.
  • Journal Title: The Journal of Neuroscience Volume: 36 Issue: 2 Pages: 375-384
  • DOI: 10.1523/jneurosci.2289-15.2016
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] パーキンソン病モデルラットにおけるグループI代謝型グルタミン酸受容体を標的としたPETイメージング (2015)
  • Author(s): 山崎友照、藤永雅之、由井譲二、脇坂秀克、河村和紀、念垣信樹、潮見聡、張明栄
  • Organizer: 第55回日本核医学会学術総会
  • Place of Presentation: ハイアットリージェンシー東京
  • Year and Date: 2015-11-05
• [Presentation] PET studies: in vivo monitoring of group I metabotropic glutamate receptors in Parkinson’s disease rat (2014)
  • Author(s): Tomoteru Yamasaki, Masayuki Fujinaga, Kazunori Kawamura, Yoko Shimoda, Kenji Furutsuka, Nobuki Nengaki, Joji Yui, Hedekatsu Wakizaka, Akiko Hatori, Lin Xie, Katsushi Kumata, Ming-Rong Zhang
  • Organizer: European Association of Nuclear Medicine Congress 2014
  • Place of Presentation: Gothenburg, Sweden
  • Year and Date: 2014-10-18 – 2014-10-22
• [Remarks] パーキンソン病の進行に伴い変化する新しいバイオマーカーを発見
  • URL: http://www.nirs.qst.go.jp/information/press/2016/01_29.shtml