| Project/Area Number |
25861135
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
Yamasaki Tomoteru 国立研究開発法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (80627563)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | PET / mGluR1 / mGluR5 / パーキンソン病 / ドーパミン / α-シヌクレイン / 代謝型グルタミン酸受容体 / ドーパミントランスポーター / DAT / Open-Field Test |
|---|
| Outline of Final Research Achievements |
In this study, dynamic changes of metabotropic glutamate receptors (mGluR1 and mGluR5) classified into group I were monitored by using longitudinal positron emission tomography (PET) in Parkinson's disease (PD) modeled animal. PET imaging demonstrated that mGluR1 expressions, but not mGluR5, dynamically changed with progression of PD pathology. Hence, it was suggested that mGluR1 might be a new biomarker for diagnostic index of PD.
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