Development of an imaging probe to estimate protoporphyrin IX accumulation induced by aminolevulinic acid

• Project/Area Number: 25861136
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Hamamatsu University School of Medicine (2015); National Institute of Radiological Sciences (2013-2014)
• Principal Investigator: Suzuki Chie 浜松医科大学, 光尖端医学教育研究センター, 助教 (20637285)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 核医学 / PET / アミノレブリン酸 / C-11 / 炭素-11

Outline of Final Research Achievements

C-11 labeled aminolevulinic　acid　derivative　([C-11]MALA)　was　developed　as　an　imaging　prove　to　estimate　tumor　protoporphyrin　IX (PpIX) accumulation indecued by exogenous aminolevulinic acid (ALA). Tumor accumulation of [C-11]MALA was correlated with that of PpIX induced by ALA, suggesting that [C-11]MALA-PET has the potential to estimate ALA-induced PpIX accumulation.

Research Products

• [Journal Article] Preclinical Characterization of 5-Amino-4-Oxo-[6-11C]Hexanoic Acid as an Imaging Probe to Estimate Protoporphyrin IX Accumulation Induced by Exogenous Aminolevulinic Acid (2014)
  • Author(s): Suzuki C, Tsuji A, Kato K, Kikuchi T, Sudo H, Okada M, Sugyo A, Zhang MR, Arano Y, Saga T
  • Journal Title: J Nucl Med Volume: 55 Issue: 10 Pages: 1671-7
  • DOI: 10.2967/jnumed.114.145086
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Synthesis and in vitro cellular uptake of 11C-labeled 5-aminolevulinic acid derivative to estimate the induced cellular accumulation of protoporphyrin IX. (2013)
  • Author(s): Suzuki C, Kato K, Tsuji AB, Kikuchi T, Zhang MR, Arano Y, Saga T.
  • Journal Title: Bioorg Med Chem Lett Volume: 23 Issue: 16 Pages: 4567-70
  • DOI: 10.1016/j.bmcl.2013.06.025
  • Peer Reviewed
• [Presentation] Development of 5-amino-4-oxo-[6-11C]hexanoic acid for estimation of tumor protoporphyrin IX accumulation induced by exogenous aminolevulinic acid (2015)
  • Author(s): Suzuki, C., Tsuji, A. B, Kato, K., Kikuchi, T., Sudo, H., Okada, M., Sugyo A., Magata, Y., Zhang, MR., Arano, Y., Saga, T.
  • Organizer: 9th Japan-China Joint Seminar on Radiopharmaceutical Chemistry
  • Place of Presentation: 放射線医学総合研究所 (千葉)
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Radiosynthesis and preclinical characterization of a 11C-labeled aminolevulinic acid derivative as an imaging probe to estimate tumor protoporphyrin IX accumulation induced by exogenous aminolevulinic acid (2014)
  • Author(s): Chie Suzuki, Atsushi B. Tsuji, Koichi Kato, Tatsuya Kikuchi, Hitomi Sudo, Aya Sugyo, Ming-Rong Zhang, Yasushi Arano, Tsuneo Saga
  • Organizer: 11 th World Federation of Nuclear Medicine and Biology
  • Place of Presentation: Cancun Center Convention & Exhibitions
  • Year and Date: 2014-08-27 – 2014-08-31
• [Presentation] 5-アミノレブリン酸を使用した光線力学療法の治療効果を予測するPETプローブの開発 (2013)
  • Author(s): 鈴木千恵、辻厚至、菊池達矢、加藤孝一、須堯綾、須藤仁美、荒野泰、佐賀恒夫
  • Organizer: 第13 回放射性医薬品・画像診断薬研究会
  • Place of Presentation: 京都 ガーデンパレス 中宴会場「鞍馬」