| Project/Area Number |
25861145
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Tokyo Metropolitan Komagome Hospital (Clinical research laboratory) |
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Principal Investigator |
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| Research Collaborator |
Karasawa Katsuyuki 都立がん・感染症センター駒込病院, 放射線診療科, 部長 (80177617)
Nihei Keizi 都立がん・感染症センター駒込病院, 放射線診療科, 医長 (30466205)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 放射線治療 / cfDNA / 遺伝子診断 / cell free DNA / 血漿DNA / 次世代シークエンサー / 肺非小細胞癌 / 血中DNA |
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| Outline of Final Research Achievements |
It was possible in this study to increase DNA derived from blood tumor to 2 times - around 30 times by the radiation exposure for the cancer tissue.
Our result indicate that cfDNA analysis after palliative radiation therapy could provide genotype informatin in radiotherapy treated cite tumor.
Cf DNA analysis after radiotherapy would be potential option in future cancer therapy.
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