| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
To enlarge donor pool for the heart transplantation, reliable method to repair the "less-than-ideal grafts". In the present study, we evaluated the merit and demerit of the oxidative phosphorylation under hypothermia. The results are summarized as follows. 1) Oxidative phosphorylation is progressed under hypothermic conditions. 2) The energy source of the ATP production under hypothermic oxygenated conditions is endogenous amino acids derived from the autophagic pathway. 3) This oxidative phosphorylation under hypothermia worsen the cellular death due to the oxidative stress. 4) Appropriate antioxidant therapy may reduced this cellular death. 5) Some proteins, probably chaperon, may actively regulate oxidative phosphorylation and autophagy under hypothermia.
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