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Study of the inhibitory effect of curcumin derivatives for the anticancer drug resistance related ABC transporter

Research Project

Project/Area Number 25861149
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionTohoku University

Principal Investigator

Katsuyoshi Kudoh  東北大学, 大学病院, 助教 (30607768)

Research Collaborator Ohbara Megumi  東北大学, 大学院生
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords抗癌剤耐性 / ABCトランスポーター / クルクミン誘導体 / Pgp発現癌細胞
Outline of Final Research Achievements

There is the acquisition of anticancer drug resistance capacity as an anti-cancer agent treatment of the problem with respect to cancer, there is an over-expression of anticancer drug resistance ABC transporter in one of the factors. In this study aimed to clarify the effect on ABC transporters curcumin derivatives.
Using carcinoma cell lines overexpressing anticancer drug resistance ABC transporters, and FACS analysis using a fluorescent substrate specific for the ABC transporter in the presence of curcumin derivative inhibitory effect of ABC transporter function was suggested. Anticancer drug sensitivity was increased to about 20-fold in the presence of curcumin derivatives examined the anticancer drug sensitivity in cell toxicity test. Potential as an inhibitor for the ABC transporter curcumin derivatives have been suggested.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2016 2015

All Presentation (3 results)

  • [Presentation] 抗癌剤耐性ABCトランスポーターに対するクルクミン誘導体の抑制効果2016

    • Author(s)
      小原 恵
    • Organizer
      第9回リトリート大学院生研究発表会
    • Place of Presentation
      仙台(東北大学医学部星陵オーディトリアム)
    • Year and Date
      2016-01-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 抗癌剤耐性ABCトランスポーターに対するクルクミン誘導体の抑制効果2015

    • Author(s)
      小原 恵
    • Organizer
      第1回疾患エピゲノムセンター冬の合宿
    • Place of Presentation
      仙台
    • Year and Date
      2015-02-14 – 2015-02-15
    • Related Report
      2014 Research-status Report
  • [Presentation] Effect of Curcumin Analogs on Multidrug Resistant ABC Transporters2015

    • Author(s)
      小原 恵
    • Organizer
      第8回リトリート 大学院生研究発表会
    • Place of Presentation
      仙台
    • Year and Date
      2015-01-17
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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