Study of the inhibitory effect of curcumin derivatives for the anticancer drug resistance related ABC transporter
| Project/Area Number |
25861149
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Research Collaborator |
Ohbara Megumi 東北大学, 大学院生
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 抗癌剤耐性 / ABCトランスポーター / クルクミン誘導体 / Pgp発現癌細胞 |
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| Outline of Final Research Achievements |
There is the acquisition of anticancer drug resistance capacity as an anti-cancer agent treatment of the problem with respect to cancer, there is an over-expression of anticancer drug resistance ABC transporter in one of the factors. In this study aimed to clarify the effect on ABC transporters curcumin derivatives.
Using carcinoma cell lines overexpressing anticancer drug resistance ABC transporters, and FACS analysis using a fluorescent substrate specific for the ABC transporter in the presence of curcumin derivative inhibitory effect of ABC transporter function was suggested. Anticancer drug sensitivity was increased to about 20-fold in the presence of curcumin derivatives examined the anticancer drug sensitivity in cell toxicity test. Potential as an inhibitor for the ABC transporter curcumin derivatives have been suggested.
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Report
(4 results)
Research Products
(3 results)
