| Project/Area Number |
25861155
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 乳癌 / HER2 / 二量体 / breast cancer / predictive factor |
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| Outline of Final Research Achievements |
The expression levels of HER2-containing dimer were evaluated in series of HER2-positive breast cancer cell lines. We also evaluated the association between expression of HER2-containing dimer and trastuzumab-sensitivity in breast cancer patients who underwent trastuzumab-containing neoadjuvant chemotherapy. HER2-containing dimer was evaluated by proximity ligation assays. There were higher expression levels of HER2-2 dimer in trastuzumab-sensitive cell lines compared to the resistant cell lines (sensitive vs. resistant, 65 vs. 15, p<0.01). In a cohort of 23 HER2-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemotherapy, high HER2-2 dimer expression cohort showed significantly higher rate of quasi-pathological complete response compared with low HER2-2 dimer expression cohort (high vs. low, 26/37, 70% vs. 2/11, 18%, p=0.006).
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