| Project/Area Number |
25861165
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Tokai University |
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Principal Investigator |
TSUDA Banri 東海大学, 医学部, 助教 (30514533)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 乳癌 / ペプチドワクチン / CH401MAP / 乳がん / HER2 / 免疫不全マウス |
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| Outline of Final Research Achievements |
① After in vitro stimulating breast cancer patient PBMC (31) in CH401MAP, and comparing the production of the specific antibody with the physically unimpaired person, production was significantly high by non-stimulation in the patient group, but the change by the stimulation was not observed. ② After transfusing patient PBMC into the mouse, and immunising it in CH401MAP, I was able to build human immune system in acknowledgment of production of human IL-2. One GVHD did not occur. The usefulness as the preclinical test mouse on observing immune system was shown. ③ I transplanted a cancer tissue piece of two breast cancer patients, but was not able to engraft into the mouse. I ported human breast cancer cell strain SKBR3, but the survival was impossible. Furthermore, the need to make condition examination was shown.
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