Examination of the effectiveness using the humanized mouse of the antiHER2 antibody epitope peptide vaccine.
| Project/Area Number |
25861165
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Tokai University |
|---|
Principal Investigator |
TSUDA Banri 東海大学, 医学部, 助教 (30514533)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 乳癌 / ペプチドワクチン / CH401MAP / 乳がん / HER2 / 免疫不全マウス |
|---|
| Outline of Final Research Achievements |
① After in vitro stimulating breast cancer patient PBMC (31) in CH401MAP, and comparing the production of the specific antibody with the physically unimpaired person, production was significantly high by non-stimulation in the patient group, but the change by the stimulation was not observed. ② After transfusing patient PBMC into the mouse, and immunising it in CH401MAP, I was able to build human immune system in acknowledgment of production of human IL-2. One GVHD did not occur. The usefulness as the preclinical test mouse on observing immune system was shown. ③ I transplanted a cancer tissue piece of two breast cancer patients, but was not able to engraft into the mouse. I ported human breast cancer cell strain SKBR3, but the survival was impossible. Furthermore, the need to make condition examination was shown.
|
Report
(3 results)
Research Products
(8 results)
-
[Journal Article] The Effect of Peptide Treatment on the HLA-Binding and Antibody Production in Peripheral Blood Mononuclear Cells Obtained from Japanese Breast Cancer Patients2015
Author(s)
Banri Tsuda*, Yoshie Kametani, Asuka Miyamoto, Hirohito Miyako, Nobue Kumaki, Rin Ogiya, Risa Oshitanai, Mayako Terao, Toru Morioka, Naoki Niikura, Takuho Okamura, Yuki Saito, Yasuhiro Suzuki and Yutaka Tokuda
-
Journal Title
Vaccines and Vaccination
Volume: 6
Issue: 01
Pages: 270-270
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Defect of tropomyosin-related kinase B isotype expression in ovarian clear cell adenocarcinoma2014
Author(s)
Goto Y, Kametani Y*, Kikugawa A, Tsuda B, Miyazawa M, Kajiwara H, Terao Y, Takekoshi S, Nakamura N, Takeda S, Mikami M
-
Journal Title
BioScience Trends
Volume: 8
Issue: 2
Pages: 93-100
DOI
NAID
ISSN
1881-7815, 1881-7823
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
