E ffect of antii TNF-a antibody against colon cancer : Does anti TNF-a antibody inhibits growth of colon cancer?
Project/Area Number |
25861169
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Digestive surgery
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Research Institution | Tohoku University |
Principal Investigator |
HANEDA Sho 東北大学, 医学(系)研究科(研究院), 大学院非常勤講師 (20436140)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | Crohn's disease / anti TNF-a / colon cancer / 抗TNF-a抗体 / 癌化 / クローン病 |
Outline of Final Research Achievements |
[Background and Aim] The risk of incidence of colorectal cancer in Crohn's disease is high. On the other hand, TNF-a inhibitors are frequently used for the treatment of Crohn's disease. There may be a risks for cancer emergence by using anti TNF-a drugs, but it is still controversial. The aim of the present study was to investigate the effect of anti TNF-a antibody for growth of colorectal cancer. [Materials and Method] We used colon cancer cell lines (COLO205, DLD1, HCT8, HCT116, HT29) and stimulate those cells with TNF-a, anti TNF-a antibody. Proliferation was determined by using CCK-8 assay. [Results and Conclusions] TNF-a reduced growth of colon cancer cells, while blockage of TNF-a by anti TNF-a antibody reduced progression of colon cancer cells. Thus, TNF-a plays a profound role in malignancy of colorectal cancer, and inhibition of TNF-a represents a promising therapeutic option.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Gastrointestinal toxicities of 5-fluorouracil increase the proportion of regulatory T cells in intestinal tract: advantages of alternate-day S-1 administration.2015
Author(s)
Kajiwara T, Miura K, Ohnuma S, Shimada M, Komura T, Toshima M, Kohyama A, Kudoh K, Haneda S, Musha H, Naitoh T, Shirasaka T, Unno M
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Journal Title
International journal of clinical oncology
Volume: 掲載確定
Related Report
Peer Reviewed
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[Journal Article] Usefulness of alternate-day administration of S-1 and leucovorin in a xenograft mouse model of colorectal cancer: a shorter drug-free interval leads to more efficient antitumor effects.2015
Author(s)
Komura T, Miura K, Shirasaka T, Ohnuma S, Shimada M, Kajiwara T, Fujishima F, Philchenkov A, Nakagawa K, Kudoh K, Haneda S, Toshima M, Kohyama A, Musha H, Naitoh T, Shibata C, Unno M
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Journal Title
International journal of clinical oncology
Volume: 20
Pages: 117-125
Related Report
Peer Reviewed
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