Trial to identify the bacteria which causes ulcerative colitis on the hypothesis that pouchitis is ulcerative ileitis
| Project/Area Number |
25861171
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
Kohyama Atsushi 東北大学, 医学(系)研究科(研究院), 非常勤講師 (50647005)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 潰瘍性大腸炎 / 回腸嚢炎 / 腸内細菌叢 / 家族性大腸腺腫症 |
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| Outline of Final Research Achievements |
Pouchitis is a major late complication which sometimes occurs after restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA). However, its pathogenesis still remains unclear. The rate of incidence is higher in ulcerative colitis’cases and quite rare in familial adenomatous polyposis' cases. Furthermore, the fact that antibiotics and probiotics are effective in treating pouchitis indicates a direct or indirect link of pouch microbiota to mucosal inflammation.
There are two aims based on the hereditary background to elucidate how microbiota in the guts alter after the patients’ operation and what causes the inflammation in the ileum, which is not supposed to have any lesions in the ulcerative colitis.
In addition, the other aim is to investigate the pathogenesis which causes ulcerative colitis according to the hypothesis that “pouchitis is ulcerative ileitis."
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Gastrointestinal toxicities of 5-fluorouracil increase the proportion of regulatory T cells in intestinal tract: advantages of alternate-day S-1 administration.2015
Author(s)
Kajiwara T, Miura K, Ohnuma S, Shimada M, Komura T, Toshima M, Kohyama A, Kudoh K, Haneda S, Musha H, Naitoh T, Shirasaka T, Unno M.
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Journal Title
Internal Journal of Clinical oncology
Volume: 20
Issue: 5
Pages: 913-21
DOI
Related Report
Peer Reviewed
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[Journal Article] Usefulness of alternate-day administration of S-1 and leucovorin in a xenograft mouse model of colorectal cancer: a shorter drug-free interval leads to more efficient antitumor effects.2015
Author(s)
Komura T, Miura K, Shirasaka T, Ohnuma S, Shimada M, Kajiwara T, Fujishima F, Philchenkov A, Nakagawa K, Kudoh K, Haneda S, Toshima M, Kohyama A, Musha H, Naitoh T, Shibata C, Unno M.
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Journal Title
Int J Clin Oncol.
Volume: 20 (1)
Issue: 1
Pages: 117-125
DOI
Related Report
Peer Reviewed / Open Access
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