| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Pouchitis is a major late complication which sometimes occurs after restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA). However, its pathogenesis still remains unclear. The rate of incidence is higher in ulcerative colitis’cases and quite rare in familial adenomatous polyposis' cases. Furthermore, the fact that antibiotics and probiotics are effective in treating pouchitis indicates a direct or indirect link of pouch microbiota to mucosal inflammation.
There are two aims based on the hereditary background to elucidate how microbiota in the guts alter after the patients’ operation and what causes the inflammation in the ileum, which is not supposed to have any lesions in the ulcerative colitis.
In addition, the other aim is to investigate the pathogenesis which causes ulcerative colitis according to the hypothesis that “pouchitis is ulcerative ileitis."
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