| Project/Area Number |
25861172
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肝星細胞 / Drug Delivery System / 肝線維化 / アデノシン / 肝線維化モデル / RT-PCR / TIMP-1 / α-SMA |
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| Outline of Final Research Achievements |
Currently, liver transplantation is the only way to treat the hepatic fibrosis , it is necessary to establish the other treatments. We have reported that hepatic fibrosis is inhibited by increased platelet. Also Platelets inhibit the activation of hepatic stellate cells via an adenine nucleotide and suppress the type Ⅰ collagen production. Retinoic acid has been reported to be a direct effect on hepatic stellate cells. Therefore, we attempted to selectively suppress hepatic fibrosis by creating a retinoic acid-modified adenosine encapsulating liposomes. Activation of TWNT-1 was confirmed to be suppressed by the addition of adenosine for TWNT-1. However, in the fibrosis model animals, it was difficult to prove the effectiveness of adenosine.
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