Does the degree of hepatic ischemia reperfusion injury differ depending on the cause of fatty liver?

Research Project

Project/Area Number	25861182
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Digestive surgery
Research Institution	Mie University
Principal Investigator	FUJII Takehiro 三重大学, 医学(系)研究科(研究院), リサーチアソシエイト (00640690)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	肝虚血再灌流傷害 / 脂肪肝 / 肝移植 / 術後合併症 / トロンボモジュリン / 治療薬 / 白血球浸潤 / 肝細胞壊死 / 虚血性再灌流障害 / 組換えヒト可溶性トロンボモジュリン / 接着分子 / フルクトース / 虚血再灌流障害 / 遺伝子組換えトロンボモジュリン / 薬物治療 / 肝虚血 / マウス
Outline of Final Research Achievements	We investigated the difference of hepatic ischemia reperfusion injury(IRI) between the fatty liver of mice caused by fat and by fructose. The results suggested more serious vulnerability to IRI in the fatty liver caused by fructose than by fat. Our present study also showed that thrombomodulin agent reduced the IRI in the fatty liver caused by fat inhibiting leukocyte invasion in injured liver.

Report

(3 results)