| Project/Area Number |
25861187
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
DOKI Yuichiro 大阪大学, 医学系研究科, 教授 (20291445)
TAKIGUCHI Shuji 大阪大学, 医学系研究科, 講師 (00301268)
MIYATA Hiroshi 大阪府立成人病センター, 消化器外科, 副部長 (80362713)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | MFG-E8 / chemotherapy / prognosis / ＭＦＧ－Ｅ８ / 抗腫瘍免疫 / 術前補助化学療法 / Treg / 食道癌 / 化学療法 / 腫瘍浸潤マクロファージ |
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| Outline of Final Research Achievements |
The expression of MFG-E8 in human esophageal squamous cell carcinoma and its influence on patient survival was investigated.
MFG-E8 expression of surgical tumor samples was examined by immunohistochemical staining in 156 cases of squamous cell esophageal carcinoma. Patients with strong MFG-E8 expression had a significantly higher rate of preoperative chemotherapy (p<0.0001). The MFG-E8 expression level did not correlated with the clinical or pathological response to the preopetarive chemotherapy. Additionally, in the group who received preoperative chemotherapy, there was significantly worse prognosis for patients with strong MFG-E8 expression (p=0.01), however for patients without preoperative chemotherapy there was no difference in survival related to MFG-E8 expression. Strong MFG-E8 expression in esophageal cancer cells may be a negative prognostic factor in patients receiving preoperative chemotherapy.
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