| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
A significant problem to be solved for patients after liver transplantation (LT) is malnutrition with anorexia in the early post-transplant period. We hypothesized that this problem was due to the change in ghrelin metabolism during LT. We examine the balance of acyl- and desacyl ghrelin (AG, DG) and the dependence of the regulation mechanism on hepatic-related enzymes in patients during LT. AG, DG, and Acyl-/total ghrelin (A/T) concentrations in blood samples were measured in patients with liver failure (LF) and patients after LT. In vitro assays using synthetic AG for assessment of de-acylation activity in serum were performed.
The AG levels and A/T ratios significantly increased in the patients with liver failure and decreased after LT because of changes in the de-acylating activity in peripheral blood. Cholinesterase (BuChE) could be an important enzyme responsible for de-acylation of AG in blood.
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