FOSB and c-Fos which constitute AP-1 expressed in the bone marrow at the advanced gastric cancer patients

• Project/Area Number: 25861200
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Kumamoto University (2014); Kyushu University (2013)
• Principal Investigator: KURASHIGE junji 熊本大学, 医学部附属病院, 特任助教 (90594474)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: AP-1 / c-FOS / FOSB / gastric cancer / 胃癌 / 腹膜播種 / activator protein-1 / c-Fos / c-Jun

Outline of Final Research Achievements

The expression levels of c-FOS and the FOSB in bone marrow and peripheral blood in was examined using 200 resected specimens to determine the clinicopathological significance. The expression levels of c-FOS and the FOSB were determined by qRT-PCR. The immunohistochemical studies for c-FOS were performed on formalin-fixed paraffin-embedded surgical sections obtained from 150 patients with gastric cancer. We also investigated the role of c-Fos and FOSB in the regulation of in vivo analysis.

Research Products

• [Journal Article] Epigenetic modulation and repression of miR-200b by cancer-associated fibroblasts contribute to cancer invasion and peritoneal dissemination in gastric cancer. (2015)
  • Author(s): Kurashige J, Mima K, Sawada G, Takahashi Y, Eguchi H, Sugimachi K, Mori M, Yanagihara K, Yashiro M, Hirakawa K, Baba H, Mimori K.
  • Journal Title: Carcinogenesis. Volume: 36 Issue: 1 Pages: 133-41
  • DOI: 10.1093/carcin/bgu232
  • Peer Reviewed / Open Access
• [Journal Article] Triangulating Stapling Technique Covered with the Pedicled Omental Flap for Esophagogastric Anastomosis: A Safe Anastomosis with Fewer Complications (2015)
  • Author(s): Yoshida N, Baba Y, Watanabe M, Hiyoshi Y, Ishimoto T, Iwagami S, Kurashige J, Sakamoto Y, Miyamoto Y, Baba H
  • Journal Title: J Am Coll Surg Volume: 220(2) Issue: 2 Pages: e13-e16
  • DOI: 10.1016/j.jamcollsurg.2014.10.015
  • Peer Reviewed
• [Journal Article] High expression of glucose transporter 1 on primary lesions of esophageal squamous cell carcinoma is associated with hematogenous recurrence (2014)
  • Author(s): Sawayama H, Ishimoto T, Watanabe M, Yoshida N, Baba Y, Sugihara H, Izumi D, Kurashige J, Baba H
  • Journal Title: Ann Surg Oncol Volume: 21(5) Issue: 5 Pages: 1756-62
  • DOI: 10.1245/s10434-013-3371-1
  • Peer Reviewed
• [Presentation] 胃癌腹膜播種におけるPLOD2の関連性 (2014)
  • Author(s): 清住 雄希
  • Organizer: 第25回日本消化器癌発生学会総会 第8回国際消化器癌発生会議
  • Place of Presentation: 福岡
  • Year and Date: 2014-11-13 – 2014-11-14
• [Presentation] 腹膜播種モデルマウスを用いた胃癌腹膜播種規定因子の解明 (2014)
  • Author(s): 藏重 淳二
  • Organizer: 第73回日本癌学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 癌腹膜播種モデルマウスを用いた腹膜播種規定因子の解明 (2014)
  • Author(s): 藏重 淳二
  • Organizer: 第46回胃病態機能研究会
  • Place of Presentation: 横浜
  • Year and Date: 2014-08-01 – 2014-08-02
• [Presentation] 胃癌骨髄中宿主細胞における転写因子AP-1（Fos/Jun）を標的とした新規治療法の確立 (2013)
  • Author(s): 藏重 淳二
  • Organizer: 第68回消化器外科学会
  • Place of Presentation: シーガイアコンベンションセンター