FOSB and c-Fos which constitute AP-1 expressed in the bone marrow at the advanced gastric cancer patients
| Project/Area Number |
25861200
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Kumamoto University (2014)
Kyushu University (2013) |
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Principal Investigator |
KURASHIGE junji 熊本大学, 医学部附属病院, 特任助教 (90594474)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | AP-1 / c-FOS / FOSB / gastric cancer / 胃癌 / 腹膜播種 / activator protein-1 / c-Fos / c-Jun |
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| Outline of Final Research Achievements |
The expression levels of c-FOS and the FOSB in bone marrow and peripheral blood in was examined using 200 resected specimens to determine the clinicopathological significance. The expression levels of c-FOS and the FOSB were determined by qRT-PCR. The immunohistochemical studies for c-FOS were performed on formalin-fixed paraffin-embedded surgical sections obtained from 150 patients with gastric cancer. We also investigated the role of c-Fos and FOSB in the regulation of in vivo analysis.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Epigenetic modulation and repression of miR-200b by cancer-associated fibroblasts contribute to cancer invasion and peritoneal dissemination in gastric cancer.2015
Author(s)
Kurashige J, Mima K, Sawada G, Takahashi Y, Eguchi H, Sugimachi K, Mori M, Yanagihara K, Yashiro M, Hirakawa K, Baba H, Mimori K.
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Journal Title
Carcinogenesis.
Volume: 36
Issue: 1
Pages: 133-41
DOI
Related Report
Peer Reviewed / Open Access
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