| Project/Area Number |
25861201
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Saga University |
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Principal Investigator |
NAKAMURA Jun 佐賀大学, 医学部, 助教 (60404175)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | TFF family / 胃癌 / 大腸癌 / メチル化 / 低酸素 / バイオマーカー / TFF1 / TFF3 / 浸潤 / 転移 / 予後マーカー / 再発マーカー / 生存 |
|---|
| Outline of Final Research Achievements |
Our data demonstrated that the expression of TFF1 was regulated by DNA methylation in gastric cancer. Furthermore, low expression of TFF1 (TFF1 methylation) in tissue samples obtained from resected gastric cancer was significantly associated with depth of cancer invasion as well as a poor prognosis. (Int J Oncol 2013)The above results were also described in the review article titled "Methylation-mediated Gene Silencing as Biomarkers of Gastric Cancer: A Review". (World J Gastroenterol 2014)
Moreover, we demonstrated that the high expression of TFF3 was associated with the presence of distant metastasis in colorectal cancer. Colorectal cancer patients with high TFF3 showed significantly worse survival in compared with patients with low TFF3. In addition, among the patients who received curative resection, high TFF3 was significantly associated with early recurrence within one year. (Int J Oncol 2015)
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