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Role of VSNL-1 overexpression in colorectal cancer patients

Research Project

Project/Area Number 25861206
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionOita University

Principal Investigator

Akagi Tomonori  大分大学, 医学部, 助教 (80572007)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsリンパ節転移 / 術後再発 / 遠隔転移 / 糖鎖 / 分子生物学的解析 / リンパ管侵襲 / 再発
Outline of Final Research Achievements

We evaluated the clinical benefits of novel predictive markers for distant recurrence with colorectal cancer using lectin microarray analysis of cell surface glycan modifications. Glycoproteins were extracted from formalin-fixed, paraffin-embedded tumor specimens and normal epithelium from 53 consecutive curatively resected stage I-III colorectal cancer cases and then subjected to lectin microarray to obtain lectin-glycan interaction (LGI) values. LGI values for Agaricus bisporus (ABA) lectin, prominent in cancer tissues, were statistically associated with distant recurrence. This ABA tumor/normal LGI ratio may be a new predictive biomarker for distant recurrence of curatively resected colorectal cancer.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2015 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (5 results)

  • [Journal Article] Establishment of new predictive markers for distant recurrence of colorectal cancer using lectin microarray analysis2015

    • Author(s)
      Nakajima K, N.Shiraishi, et al.
    • Journal Title

      Cancer Med.

      Volume: 4(2) Issue: 2 Pages: 293-302

    • DOI

      10.1002/cam4.342

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased expression of Bauhinia purpurea lectin is a predictor of gastric cancer recurrence2015

    • Author(s)
      T.Futsukaichi, et al
    • Journal Title

      Surgery Today

      Volume: なし

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] レクチンマイクロアレイ解析を用いた新しい大腸癌遠隔再発予測マーカーの確立2015

    • Author(s)
      中嶋健太郎ら
    • Organizer
      第6回癌・炎症と抗酸化研究会
    • Place of Presentation
      ホルトホール大分(大分)
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] Establishment of novel predictive markers for distant recurrence of colorectal cancer using lectin microarray analysis2015

    • Author(s)
      中嶋健太郎ら
    • Organizer
      第53回日本癌治療学会総会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] レクチンマイクロアレイを用いた胃癌再発予測因子レクチンBPLの同定2015

    • Author(s)
      二日市啄良ら
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report 2014 Research-status Report
  • [Presentation] 大腸癌におけるリンパ節転移および予後不良の指標としてのVisinin-like protein-1(VSNL-1)発現の有用性2013

    • Author(s)
      赤木智徳、猪股雅史、二日市琢良、杉田 諭、草野 徹、中嶋健太郎、平塚孝宏、柴田智隆、上田貴威、當寺ヶ盛学、白下英史、衛藤 剛、野口 剛、白石憲男、北野正剛
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] 高感度レクチンアレイを用いた大腸癌の糖鎖プロファイリング―移転、再発に関与するレクチンの同定―2013

    • Author(s)
      中嶋健太郎、猪股雅史、平塚孝宏、二日市琢良、杉田 諭、赤木智隆、上田貴威、白下英史、衛藤 剛、野口 剛、白石憲男、北野正剛
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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