Pancreatic stellate cells specific HSP47 genetic control promote pancreatic regeneration
| Project/Area Number |
25861207
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
OTA Shigenori 札幌医科大学, 医学部, 研究員 (90457705)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 膵再生 / 膵星細胞 / 再生医療 / HSP47 / 薬物輸送システム |
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| Outline of Final Research Achievements |
Pancreatic acinar cells(Pacs) and Islet cells(Ics) vigorously proliferated after 90% pancreatectomy. In addition, Pacs proliferation was facilitated by co-culture with pancreatic stellate cells(Pscs). HSP 47 activation in Pscs plays an important role in the proliferation of Pacs, which was totally blocked by HSP47-specific siRNA delivery in vivo and in vitro. Therefore, HSP47 expression in Pscs would be necessary to promote pancreatic regeneration.
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] Activated hepatic stellate cells are dependent on self-collagen, cleaved by membrane type 1 matrix metalloproteinase for their growth.2014
Author(s)
Birukawa NK, Murase K, Sato Y, Kosaka A, Yoneda A, Nishita H, Fujita R, Nishimura M, Ninomiya T, Kajiwara K, Miyazaki M, Nakashima Y, Ota S, Murakami Y, Tanaka Y, Minomi K, Tamura Y, Niitsu Y
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Journal Title
the journal of biological chemistry
Volume: 289(29)
Pages: 20209-20221
Related Report
Peer Reviewed
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