| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Extrahepatic cells have been considered a potential cellular resource for liver regeneration in response to liver damages. The genotyping of human living donor liver transplant recipients has reported that cells derived from those recipients of living donor liver transplantation differentiated into multiple types of liver component cells, suggesting that extrahepatic, as well as multipotent, cells contributed to liver regeneration.
Excessive portal vein pressure have been considered a disadvantage factor for liver regeneration. We measured portal vein pressure and liver volume simultaneously. That result show that just after splenectomy portal vein pressure didn’t go down but one week after operation portal vein pressure went down and liver regeneration was increasing than not splenectomy group. Splenectomy can avoid excessive portal vein pressure and promote liver regeneration at excessive liver resection or liver transplantation.
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