| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Vasohibin-2 has been identified as an extrinsic and vascular endothelial growth factor independent angiogenic factor that is highly expressed in tumor cells. In the present study, we aimed to find whether pre-existing vascular changes can be used to predict tumor transformation as benign or malignant. We sought to characterize the microvascular changes and tumor development in the intestinal tract of ApcMin/+ mice and the ApcMin/+/Vash2-/- mice. ApcMin/+/Vash2-/- mice showed a significant decrease in the number of polyps in the intestine. In addition, functional tumor blood vessels were decreased, and pericyte coverage tumor vessels were increased. On the other hand, the expression of Epiregulin and IL-6 family was down-regulated in ApcMin/+/Vash2-/- mice. And also, the M2 like Macrophage was decreased in tumors of ApcMin/+/Vash2-/- mice. These results indicated that VASH2 regulates tumor onset in the gastrointestinal tract by changing tumor microenvironment.
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