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Total Artificial Heart using Anatomically Compatible Helical Inflow Centrifugal Blood Pumps

Research Project

Project/Area Number 25861225
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cardiovascular surgery
Research InstitutionTohoku University

Principal Investigator

Miura Hidekazu  東北大学, 加齢医学研究所, 助教 (50451894)

Co-Investigator(Renkei-kenkyūsha) SHIRAISHI Yasuyuki  東北大学, 加齢医学研究所, 准教授 (00329137)
YAMBE Tomoyuki  東北大学, 加齢医学研究所, 教授 (70241578)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords全置換型人工心臓 / 解剖学的適合性 / 定常流血液ポンプ / 左右血流バランス / 心房拍動 / 人工心肺 / 経皮的電力伝送システム / ワンポイント転がり軸受 / 遠心型血液ポンプ / 数値流体解析 / 血液適合性 / 遠心血液ポンプ / モノピボット軸受 / pwave / 心房収縮
Outline of Final Research Achievements

In an acute animal experiment, the total artificial circulation model was made using the centrifugal type after marketing ,left ventricular assist devices, the regular way, an achieved possibility of the centrifugal type blood pump total artificial heart was indicated. An atrium pulse was kept in the total artificial heart animal experiment model, and we found that physiological control by automatic nerves system control might be achieved. A concept model of the total artificial heart was made using a three-dimensional printer and fitting study was performed in adult goats of sacrifice after the other experiments. The independent left and right blood pumps type total artificial heart concept of was indicated by miniaturizing the blood pumps. It was low in cost and a small embroidered design in one constraint ball bearing aiming longer durability was contrived and the movement was confirmed in a prototype pump.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (18 results)

All 2016 2015 2014 2013

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (13 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Hemodynamics of a Functional Centrifugal-Flow Total Artificial Heart with Functional Atrial Contraction in Goats2016

    • Author(s)
      Shiga T, Shiraishi Y, Sano K, Taira Y, Tsuboko Y, Yamada A, Miura H, Katahira S, Akiyama M, Saiki Y, Yambe T
    • Journal Title

      Journal of Artificial Organs

      Volume: 19(1) Issue: 1 Pages: 8-13

    • DOI

      10.1007/s10047-015-0852-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fundamental Analysis and Development of the Current and Voltage Control Method by Changing the Driving Frequency for the Transcutaneous Energy Transmission System2015

    • Author(s)
      H. Miura, A. Yamada, Y. Shiraishi, T. Yambe
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc

      Volume: 2015 Pages: 1319-1322

    • DOI

      10.1109/embc.2015.7318611

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Discrimination ability and reproducibility of a new index reflecting autonomic nervous function based on pulsatile amplitude of photoplethysmography2014

    • Author(s)
      Kano Y, Yoshizawa M, Sugita N, Abe M, Homma N, Tanaka A, Yamauchi T, Miura H, Shiraishi Y, Yambe T
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc

      Volume: 2014 Pages: 1794-1800

    • DOI

      10.1109/embc.2014.6943957

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A new control method depending on primary phase angle of transcutaneous energy transmission system for artificial heart.2013

    • Author(s)
      Miura H, Saito I, Sato F, Shiraishi Y, Yambe T, Matsuki H
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc. 2013

      Volume: - Pages: 5723-6

    • DOI

      10.1109/embc.2013.6610850

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hemodynamic Effects of Pressure-Volume Relation in the Atrial2013

    • Author(s)
      Takuya Shiga, Takehito Kuroda, Yusuke Tsuboko, Hidekazu Miura, Yasuyuki Shiraishi, and Tomoyuki Yambe
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc

      Volume: 2013 Pages: 1815-1818

    • DOI

      10.1109/embc.2013.6609875

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 全置換型人工心臓用右心ポンプの新しい支持駆動部分の開発2016

    • Author(s)
      三浦英和
    • Organizer
      第55回日本生体医工学会大会
    • Place of Presentation
      富山市民プラザ(富山県、富山市)
    • Year and Date
      2016-04-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 完全埋め込み型人工心臓のための体内二次電池直接充電を用いた経皮的電力伝送システムの試作2015

    • Author(s)
      三浦英和
    • Organizer
      第53回日本人工臓器学会大会
    • Place of Presentation
      東京ドームホテル(東京都、文京区)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Fundamental analysis and development of the current and voltage control method by changing the driving frequency for the transcutaneous energy transmission system.2015

    • Author(s)
      三浦英和
    • Organizer
      IEEE EMBC 2015
    • Place of Presentation
      イタリア、ミラノ
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 完全埋め込み型人工心臓のための経皮的電力伝送システムにおける体内二次電池の直接充電の検討2015

    • Author(s)
      三浦英和
    • Organizer
      第43回人工心臓と補助循環懇話会学術集会
    • Place of Presentation
      静岡県熱海市
    • Year and Date
      2015-02-20 – 2015-02-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 心房を温存した遠心ポンプ全置換型人工心臓の開発2015

    • Author(s)
      萩尾勇樹 三浦英和
    • Organizer
      第43回人工心臓と補助循環懇話会学術集会
    • Place of Presentation
      静岡県熱海市
    • Year and Date
      2015-02-20 – 2015-02-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 小型化した遠心型補助人工心臓 EVAHEART の慢性動物実験の血液動態の評価2014

    • Author(s)
      三浦英和
    • Organizer
      第52回日本人工臓器学会大会
    • Place of Presentation
      北海道 札幌市
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 形状記憶合金線維を用いた人工臓器に対する経皮的電力伝送システムの充電電流制御シ ステムの構築2014

    • Author(s)
      三浦英和
    • Organizer
      第52回日本人工臓器学会大会
    • Place of Presentation
      北海道 札幌市
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 遠心ポンプを用いた TAH の駆動部の設計と試作2014

    • Author(s)
      萩尾勇樹、三浦英和、白石泰之、山家智之
    • Organizer
      日本定常流ポンプ研究会 2014
    • Place of Presentation
      北海道 札幌市
    • Year and Date
      2014-10-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 形状記憶合金線維を用いた人工臓器のための体内蓄電システムを用いた経皮的電力伝送に関する基 礎的検討 Examintion of the transcutaneous transmission system with the internal energy storage system for artificial organs using shape memory alloy fiber2014

    • Author(s)
      三浦 英和
    • Organizer
      53回日本生体医工学会大会
    • Place of Presentation
      宮城県 仙台市
    • Year and Date
      2014-06-24 – 2014-06-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 形状記憶合金線維を用いた循環補助デバイスに対する経皮的電力伝送に関する検討2014

    • Author(s)
      三浦英和、山田昭博、ハシム モハメド オムラン、白石泰之、佐藤文博、山家智之、松木英敏
    • Organizer
      第42回人工心臓と補助循環懇話会学術集会
    • Place of Presentation
      新潟県越後湯沢
    • Related Report
      2013 Research-status Report
  • [Presentation] 心房を温存した遠心血液ポンプ型全置換型人工心臓における基礎的研究2014

    • Author(s)
      志賀卓弥、坪子侑佑、佐野恭介、平恭紀、伊藤拓哉、山田昭博、ハシム モハメド オムラン、三浦英和、白石泰之、山内正憲、山家智之
    • Organizer
      第42回人工心臓と補助循環懇話会学術集会
    • Place of Presentation
      新潟県越後湯沢
    • Related Report
      2013 Research-status Report
  • [Presentation] A new control method depending on primary phase angle of transcutaneous energy transmission system for artificial heart.2013

    • Author(s)
      Miura H, Saito I, Sato F, Shiraishi Y, Yambe T, Matsuki H
    • Organizer
      35th Annual international conference of IEEE EMBS
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Hemodynamic effects of pressure-volume relation in the atrial contraction model on the total artificial heart using centrifugal blood pumps.2013

    • Author(s)
      Shiga T, Kuroda T, Tsuboko Y, Miura H, Shiraishi Y, Yambe T.
    • Organizer
      35th Annual international conference of IEEE EMBS
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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