Examination of ONO-1301 for inhibitory effect of paravalvular leak following transcatheter aortic valve implantation

• Project/Area Number: 25861228
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular surgery
• Research Institution: Osaka University
• Principal Investigator: MAEDA Koichi 大阪大学, 医学部附属病院, 特任助教 (50644994)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 弁周囲逆流 / 経カテーテル的大動脈弁植込み術 / 経カテーテル的大動脈弁植込術

Outline of Final Research Achievements

The aim of this study was to examine the inhibitory effects of ONO-1301 for paravalvular leak following transcatheter aortic valve implantation. The stent grafts with gelatin hydrogel including ONO-1301 and bone fragment, were implanted on the aorta on HBD dogs. The paravalvular leak was reduced over time until one month, but, was unchanged after one month. The histology revealed the fibrous tissue and intimal proliferation between the aorta and the bone fragment. ONO-1301 may be useful to prohibit paravalvular leak following transcatheter aortic valve implantation.