Haemodynamic unloading increases the survival and affects the differentiation of cardiac stem cells after implantation into an infarcted heart

• Project/Area Number: 25861229
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular surgery
• Research Institution: Yamaguchi University
• Principal Investigator: KURAZUMI Hiroshi 山口大学, 医学部附属病院, 助教 (50645116)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 心筋再生 / メカニカルストレス / 細胞治療

Outline of Final Research Achievements

It has been anticipated that stem cell therapy is capable of repairing an injured heart but is currently limited by its marginal efficacy. We believe that mechanical stress due to haemodynamic loading may negate the therapeutic potency of stem cells and therefore investigated how haemodynamic unloading affects the survival and differentiation of stem cells after implantation into an infarcted heart.
Haemodynamic unloading favours the survival/engraftment of donor stem cells and affects their differentiation after implantation into an infarcted heart. Although further studies in a large animal model are required to investigate the functional benefits of haemodynamic unloading on stem cell therapy, we may temporarily unload the damaged heart to enhance cell engraftment and then load the heart again to induce the differentiation of stem cells.

Research Products

• [Journal Article] Haemodynamic unloading increases the survival and affects the differentiation of cardiac stem cells after implantation into an infarcted heart (2014)
  • Author(s): Kurazumi H, Li TS, Takemoto Y, Suzuki R, Mikamo A, Guo CY, Murata T, Hamano K
  • Journal Title: European Journal of Cardio-Thoracic Surgery Volume: Epub ahead of print Issue: 6 Pages: 1-7
  • DOI: 10.1093/ejcts/ezt629
  • Peer Reviewed
• [Journal Article] Aortic arch surgery in octogenarians: is it justified? (2014)
  • Author(s): Kurazumi H, Mikamo A, Kudo T, Suzuki R, takahashi M, Shirasawa B, Zempo N, Hamano K
  • Journal Title: Eur J Cardiothorac Surg Volume: Epub ahead of print Issue: 4 Pages: 1-6
  • DOI: 10.1093/ejcts/ezu056
  • Peer Reviewed