| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Outline of Final Research Achievements |
Purpose: The aim of this study was to evaluate the effectiveness of the controlled release of PRP. Methods: After median sternotomy and bilateral internal thoracic artery removal, 16 rabbits were randomized into 4 groups: control (ctrl), 30mg of gelatin-hydrogel incorporating 300μl of PBS (gel), 300μl of the solution form of PRP (PRP), 30mg of gelatin-hydrogel incorporating 300μl of PRP (PRP+gel). Results: This study demonstrated that a controlled release of PRP increases the bone mineral density of sponge bone (382.7±40.1mg/cm3) compared with Ctrl, gel, and PRP (265.4±18.9, 325.6±41.4, 285.4±31.5mg/cm3, respectively p<0.01). Histologic analysis of PRP+gel group revealed accumulation of fibrous tissue into the separated sternal space. Apparent sternal dehiscence was observed in the Ctrl, gel, PRP as assessed radio graphically. Conclusion: Controlled release PRP system is markedly effective in encouraging sternal healing on early phase.
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