The role of IL-6 in molecular pathogenesis of abdominal aortic aneurysm and its therapeutic implication
| Project/Area Number |
25861238
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 大動脈瘤 / 慢性炎症 / 炎症性サイトカイン / IL-6 / STAT3 / 細胞外マトリクス / 炎症制御 / JAK/STAT系 / 炎症 / ＩＬ－6 |
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| Outline of Final Research Achievements |
Abdominal aortic aneurysm (AAA) is characterized by chronic inflammation and destruction of aortic walls with no established pharmacotherapy. In this study, we investigated into the role of IL-6 in AAA pathogenesis using mouse model of AAA that was induced by periaortic application of CaCl2. Systemic administration of the IL-6 receptor blocking antibody (MR16-1) suppressed formation of AAA in mice. Histological findings indicated less destruction of AAA wall with MR16-1 treatment. Immunofluorescence staining and imaging cytometric analysis revealed the activation of Smad2, an effector of TGF-beta signal. Consistently, biochemical studies showed suppression of MMP-2 and enhancement of lysyl oxidase expression. Therefore, IL-6 promotes AAA formation in the mouse model and its suppression has a therapeutic potential.
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Report
(3 results)
Research Products
(11 results)
