Receptor tyrosine kinase-like orphan receptor 1 as immunotherapeutic targets for lung adenocarcinoma

Research Project

Project/Area Number	25861239
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Respiratory surgery
Research Institution	Asahikawa Medical College
Principal Investigator	HAYASHI SATOSHI 旭川医科大学, 医学部, 助教 (10463754)
Project Period (FY)	2013-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	ROR1 / 肺癌 / 免疫療法 / 癌免疫療法 / 肺腺癌 / EGFR
Outline of Final Research Achievements	Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is highly expressed in LC and since the expression of molecules in normal tissue is significantly lower as compared to tumor cells, these proteins are considered as potential tumor-associated antigens (TAAs) for developing T-cell based immunotherapy.