The study of obliterans bronchiolitis immunopathogenisis and therapy after lung transplant.
| Project/Area Number |
25861240
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory surgery
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| Research Institution | Chiba University |
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Principal Investigator |
Suzuki Hidemi 千葉大学, 医学(系)研究科(研究院), 助教 (60422226)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 肺移植 / 拒絶反応 / 肺再生 / 自己免疫 |
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| Outline of Final Research Achievements |
Due to no effective therapies for obliterative bronchiolitis(OB), the leading cause of death in lung transplant patients, there has been an intensive search for pre-clinical models that replicate OB. We initiated the OB model using minor histoincompatible antigen murine orthotopic single-left lung transplants.
We reported that minor, but not major, histocompatibility antigens account for the 50% rate of OB after 28 day after transplant in murine orthotopic lung transplants. IL-10 induction was associated with the absence of OB, whereas, OB development was IL-17 dependent.Donor mice derived minor histoincompatible antigen contribute to OB development and IL-17 induction. Strategies to identifyminor histoincompatible antigen and prevent IL-17 induction in clinical lung transplantation could be useful to reduce the risk of OB development.
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Report
(4 results)
Research Products
(2 results)
