How cancer cells condition fibroblasts for metastasis with them?
| Project/Area Number |
25861249
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
HATO Tai 慶應義塾大学, 医学部, 助教 (10365281)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肺癌 / 共培養 / 線維芽細胞 / 細胞集塊型転移 / 転移 / 癌微小環境 / 集塊型転移 / スフェロイド共培養 / 上皮間質移行関連シグナル |
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| Outline of Final Research Achievements |
1) As a result of co-culture of cancer cells and fibroblasts, their form was changed in a strange morphology. 2) As a result of co-culture of cancer cells and fibroblasts, cell proliferation activity and anti-apoptotic activity was shown to increase. 3) As a result of co-culture of cancer cells and fibroblasts, anti-cytotoxic drug resistance was increased. But they not effect for resistance to EGFR-TKIs.4) As a result of co-culture of cancer cells and fibroblasts, the expression of angptl4 in them was enhanced, but the detailed mechanism is necessary to examine.5)We tried to create the in vivo model to examine the relevance of spheroid co-culture for metastasis
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Report
(3 results)
Research Products
(3 results)
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[Journal Article] Ezrin-expressing lung adenocarcinoma cells and podoplanin-positive fibroblasts form a malignant microenvironment2015
Author(s)
Suzuki S, Ishii G, Matsuwaki R, Neri S, Hashimoto H, Yamauchi C, Aokage K, Hishida T, Yoshida J, Kohno M, Nagai K, Ochiai A.
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Journal Title
J Cancer Res Clin Oncol.
Volume: 141
Pages: 475-484
Related Report
Peer Reviewed
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