Development of a novel therapy targeting tumor microenvironment of malignant pleural mesothelioma

• Project/Area Number: 25861255
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: Kyushu University
• Principal Investigator: Morodomi Yosuke 九州大学, 医学(系)研究科(研究院), 助教 (60645365)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 悪性胸膜中皮腫 / ウロキナーゼ / ウロキナーゼ受容体

Outline of Final Research Achievements

We examined the relationship between the expression of urokinase-type plasminogen activator receptor (uPAR) and the clinicopathologic features of malignant pleural mesothelioma. As a result, the patients with high expression of uPAR had significantly shorter prognosis than the low expression patients. Additionally, we found hypoxic condition promote the expression of uPAR in mesothelioma cell lines, suggesting that the condition facilitate the invasiveness of mesothelioma. Therefore, suppressing uPAR may be a novel target of malignant pleural mesothelioma for treatment or diagnosis.

Research Products

• [Journal Article] Associations Between Driver Gene Mutations and Cytotoxic Chemosensitivity in Patients with Non-small Cell Lung Cancer. (2015)
  • Author(s): Morodomi Y, Okamoto T, Kohno M, Katsura M, Takada K, Suzuki Y, Fujishita T, Kitahara H, Shimamatsu S, Yoshida T, Tagawa T, Okano S, Maehara Y
  • Journal Title: Anticancer Research Volume: 35 Pages: 1791-1796
  • Peer Reviewed
• [Journal Article] Clinical significance of detecting somatic gene mutations in surgically resected adenosquamous cell carcinoma of the lung in Japanese patients (2014)
  • Author(s): Morodomi Y, Okamoto T, Takenoyama M, Takada K, Katsura M, Suzuki Y, Fujishita T, Kitahara H,
  • Journal Title: Ann Surg Oncol Volume: in press Issue: 8 Pages: 2593-8
  • DOI: 10.1245/s10434-014-4218-0
  • Peer Reviewed / Open Access
• [Presentation] 悪性胸膜中皮腫における線溶系分子の発現と臨床病理学的因子に関する検討 (2014)
  • Author(s): 諸富洋介、他
  • Organizer: 第55回日本肺癌学会学術集会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2014-11-14 – 2014-11-16
• [Presentation] 悪性胸膜中皮腫におけるウロキナーゼ型プラスミノーゲン活性化因子受容体の発現と臨床病理学的因子に関する検討 (2014)
  • Author(s): 諸富洋介、他
  • Organizer: 第67回日本胸部外科学会定期学術集会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2014-09-30 – 2014-10-03