The mechanism of accumlation of tracer for FMT-PET in malignant brain tumors

• Project/Area Number: 25861256
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: University of the Ryukyus (2014-2015); Gunma University (2013)
• Principal Investigator: Sugawara Kenichi 琉球大学, 医学部附属病院, 講師 (50375573)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 神経膠腫 / PET検査 / L型アミノ酸トランスポーター

Outline of Final Research Achievements

Usefulness of positron emission tomography with amino acid tracer FMT(FMT-PET) for diagnosis of malignant brain tumors and the mechanism of its specific accumulation in tumor tissues were analyzed. FMT-PET was considered useful for diagnosis of WHO grade (malignancy) and histological type in glioma. In addition, system L type neutral amino acid transporter LAT-1 were highly expressed in tumor cells and tumor vessel endothelial cells in immunohistochemical study. Because the intensity of LAT-1 expression was significantly correlated with WHO grade(malignancy), suggested that accumulation of FMT to tumor tissues may be strongly involved by the intensity of LAT-1 expression.