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The mechanism of accumlation of tracer for FMT-PET in malignant brain tumors

Research Project

Project/Area Number 25861256
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionUniversity of the Ryukyus (2014-2015)
Gunma University (2013)

Principal Investigator

Sugawara Kenichi  琉球大学, 医学部附属病院, 講師 (50375573)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords神経膠腫 / PET検査 / L型アミノ酸トランスポーター
Outline of Final Research Achievements

Usefulness of positron emission tomography with amino acid tracer FMT(FMT-PET) for diagnosis of malignant brain tumors and the mechanism of its specific accumulation in tumor tissues were analyzed. FMT-PET was considered useful for diagnosis of WHO grade (malignancy) and histological type in glioma. In addition, system L type neutral amino acid transporter LAT-1 were highly expressed in tumor cells and tumor vessel endothelial cells in immunohistochemical study. Because the intensity of LAT-1 expression was significantly correlated with WHO grade(malignancy), suggested that accumulation of FMT to tumor tissues may be strongly involved by the intensity of LAT-1 expression.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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