|Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|Outline of Final Research Achievements
Usefulness of positron emission tomography with amino acid tracer FMT(FMT-PET) for diagnosis of malignant brain tumors and the mechanism of its specific accumulation in tumor tissues were analyzed. FMT-PET was considered useful for diagnosis of WHO grade (malignancy) and histological type in glioma. In addition, system L type neutral amino acid transporter LAT-1 were highly expressed in tumor cells and tumor vessel endothelial cells in immunohistochemical study. Because the intensity of LAT-1 expression was significantly correlated with WHO grade(malignancy), suggested that accumulation of FMT to tumor tissues may be strongly involved by the intensity of LAT-1 expression.