The role of a novel platelet activated receptor CLEC-2 in the carotid plaque

• Project/Area Number: 25861265
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: University of Yamanashi
• Principal Investigator: HASHIMOTO Koji 山梨大学, 総合研究部, 助教 (10644792)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 頚動脈プラーク / CLEC-2 / ポドプラニン / 頚部頚動脈狭窄症 / 不安定プラーク / 頚部内頚動脈狭窄症 / アテローム血栓 / CLEC2 / プラークイメージ / 頸動脈プラーク

Outline of Final Research Achievements

The vulnerability of the carotid plaque is strongly associated with cerebral infarction. However, the mechanism has not been elucidated. On the other hand, C-type lectin-like receptor 2 (CLEC2), a novel platelet activated receptor, is suggested to participate in the vulnerability of the atheromatous plaque, cooperating with its ligand podplanin. Immunohistochemical analysis indicated that podoplanin was localized to macrophages and smooth muscle cell in the intima of carotid artery. Vulnerable plaque by preoperative diagnostic MR plaque imaging and symptomatic lesions were more likely to express podoplanin.