Search to the future of the IV t-PA therapy

• Project/Area Number: 25861266
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Gifu University
• Principal Investigator: TAKAGI Toshinori 岐阜大学, 医学部附属病院, 助教 (00452152)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: t-PA静注療法 / 塩酸ファスジル / 血管内皮細胞

Outline of Final Research Achievements

As for the thrombolysis therapy using intravenous t-PA for the cerebral infarction, the treatable time is strictly limited within 3 hours after onset because of complications called cerebral hemorrhage. We showed that fasudil decreased the hemorrhagic transformation using a mouse model. It was shown that fasudil prevent hemorrhagic infarction by protecting vascular endothelium whereas t-PA itself had the toxicity for vascular endothelial cells. These results shows the possibility that treatable time of the cerebral infarction can be extended in the future.

Research Products

• [Journal Article] Early Neurologic Improvement Based on the National Institutes of Health Stroke Scale Score Predicts Favorable Outcome within 30 Minutes after Undergoing Intravenous Recombinant Tissue Plasminogen Activator Therapy. (2014)
  • Author(s): Takagi T, Kato T, Sakai H, Nishimura Y
  • Journal Title: J Stroke Cerebrovasc dis Volume: 23 Issue: 1 Pages: 69-74
  • DOI: 10.1016/j.jstrokecerebrovasdis.2012.09.013
  • Peer Reviewed / Open Access
• [Journal Article] Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusionin jury (2014)
  • Author(s): Toshinori Takagi, Akira Kitashoji, Takao Iwawaki, Kazuhiro Tsuruma, Masamitsu Shimazawa, Shinichi Yoshimura, Toru Iwama, Hideaki Hara
  • Journal Title: Free Radic. Biol. Med. Volume: 72 Pages: 124-133
  • DOI: 10.1016/j.freeradbiomed.2014.04.009
  • Peer Reviewed / Open Access
• [Journal Article] The phosphodiesterase Ⅲ inhibitor cilostazol ameliorates ethanolinduced endothelial dysfunction. (2014)
  • Author(s): Takagi T, Mishiro K, Shimazawa M, Yoshimura S, Iwama T, Hara H
  • Journal Title: Curr Neurovasc Res Volume: 11 Pages: 302-311
  • Peer Reviewed
• [Journal Article] Glycoprotein nonmetastatic melanoma protein B (GPNMB) as a novel neuroprotective factor in cerebral ischemia-reperfusion injury. (2014)
  • Author(s): Nakano Y, Suzuki Y, Takagi T, Kitashoji A, Ono Y, Tsuruma K, Yoshimura S, Shimazawa M, Iwama T, Hara H
  • Journal Title: Neuroscience Volume: 277 Pages: 123-131
  • DOI: 10.1016/j.neuroscience.2014.06.065
  • Peer Reviewed / Open Access
• [Journal Article] Diabetes mellitus aggravates hemorrhagic transformation after ischemic stroke via mitochondrial defects leading to endothelial apoptosis. (2014)
  • Author(s): Mishiro K, Imai T, Sugitani S, Kitashoji A, Suzuki Y, Takagi T, Chen H, Oumi Y, Tsuruma K, Shimazawa M, Hara H
  • Journal Title: PLoS One Volume: 9 Issue: 8 Pages: e103818-e103818
  • DOI: 10.1371/journal.pone.0103818
  • Peer Reviewed / Open Access
• [Journal Article] rt－PA 治療後の血管内治療―RCTの結果から―． (2014)
  • Author(s): 髙木俊範, 吉村紳一
  • Journal Title: 分子脳血管病 Volume: 13 Pages: 47-52
  • Peer Reviewed / Open Access
• [Journal Article] 緊急脳血管内治療時における抗血小板薬loading dese投与後の薬効解析. (2014)
  • Author(s): 榎本由貴子, 吉村紳一, 髙木俊範, 辻本真範, 石澤錠二, 岩間 亨
  • Journal Title: JNET Volume: 8 Pages: 251-258
  • Peer Reviewed / Open Access
• [Presentation] コラゲナーゼ誘発脳出血に対するシロスタゾールの作用. (2015)
  • Author(s): 髙木俊範, 三代圭介, 辻本真範, 今井貴彦, 永嶌一紀, 嶋澤雅光, 吉村紳一, 小澤 修, 岩間 亨, 原 英彰
  • Organizer: 第40回日本脳卒中学会総会
  • Place of Presentation: 広島
  • Year and Date: 2015-03-26 – 2015-03-29
• [Presentation] 術前t-PA静注療法が急性期再開通療法後出血に与える影響-RESCUE Japan Registryより-. (2014)
  • Author(s): 髙木俊範, 吉村紳一, 榎本由貴子, 江頭裕介, 山上 宏, 坂井信幸, 岡田 靖, 北川一夫, 木村和美, 棚橋紀夫, 瓢子敏夫
  • Organizer: 第30回日本脳神経血管内治療学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-12-04 – 2014-12-06
• [Presentation] エタノール誘発血管内皮障害に対するシロスタゾールの保護作用. (2014)
  • Author(s): 髙木俊範, 三代圭介, 今井貴彦, 嶋澤雅光, 岩間 亨, 原 英彰
  • Organizer: 第26回日本脳循環代謝学会総会
  • Place of Presentation: 岡山
  • Year and Date: 2014-11-21 – 2014-11-22
• [Presentation] 転写因子Nrf2活性化剤による脳虚血再灌流障害に対する神経保護の検討. (2014)
  • Author(s): 髙木俊範, 北庄司輝, 岩脇隆夫, 嶋澤雅光, 吉村紳一, 岩間 亨, 原 英彰
  • Organizer: 第73回日本脳神経外科学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-09 – 2014-10-11
• [Book] 循環器疾患 最新の治療2014-2015 (2014)
  • Author(s): 髙木俊範, 吉村紳一
  • Total Pages: 5
  • Publisher: 南江堂
• [Remarks] 岐阜大学医学部脳神経外科
  • URL: http://www.med.gifu-u.ac.jp/neurosurgery/
• [Remarks] 岐阜大学医学部脳神経外科
  • URL: http://www.med.gifu-u.ac.jp/neurosurgery/