• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Search to the future of the IV t-PA therapy

Research Project

Project/Area Number 25861266
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionGifu University

Principal Investigator

TAKAGI Toshinori  岐阜大学, 医学部附属病院, 助教 (00452152)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordst-PA静注療法 / 塩酸ファスジル / 血管内皮細胞
Outline of Final Research Achievements

As for the thrombolysis therapy using intravenous t-PA for the cerebral infarction, the treatable time is strictly limited within 3 hours after onset because of complications called cerebral hemorrhage. We showed that fasudil decreased the hemorrhagic transformation using a mouse model. It was shown that fasudil prevent hemorrhagic infarction by protecting vascular endothelium whereas t-PA itself had the toxicity for vascular endothelial cells. These results shows the possibility that treatable time of the cerebral infarction can be extended in the future.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (14 results)

All 2015 2014 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 6 results) Presentation (4 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Early Neurologic Improvement Based on the National Institutes of Health Stroke Scale Score Predicts Favorable Outcome within 30 Minutes after Undergoing Intravenous Recombinant Tissue Plasminogen Activator Therapy.2014

    • Author(s)
      Takagi T, Kato T, Sakai H, Nishimura Y
    • Journal Title

      J Stroke Cerebrovasc dis

      Volume: 23 Issue: 1 Pages: 69-74

    • DOI

      10.1016/j.jstrokecerebrovasdis.2012.09.013

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusionin jury2014

    • Author(s)
      Toshinori Takagi, Akira Kitashoji, Takao Iwawaki, Kazuhiro Tsuruma, Masamitsu Shimazawa, Shinichi Yoshimura, Toru Iwama, Hideaki Hara
    • Journal Title

      Free Radic. Biol. Med.

      Volume: 72 Pages: 124-133

    • DOI

      10.1016/j.freeradbiomed.2014.04.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The phosphodiesterase Ⅲ inhibitor cilostazol ameliorates ethanolinduced endothelial dysfunction.2014

    • Author(s)
      Takagi T, Mishiro K, Shimazawa M, Yoshimura S, Iwama T, Hara H
    • Journal Title

      Curr Neurovasc Res

      Volume: 11 Pages: 302-311

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glycoprotein nonmetastatic melanoma protein B (GPNMB) as a novel neuroprotective factor in cerebral ischemia-reperfusion injury.2014

    • Author(s)
      Nakano Y, Suzuki Y, Takagi T, Kitashoji A, Ono Y, Tsuruma K, Yoshimura S, Shimazawa M, Iwama T, Hara H
    • Journal Title

      Neuroscience

      Volume: 277 Pages: 123-131

    • DOI

      10.1016/j.neuroscience.2014.06.065

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diabetes mellitus aggravates hemorrhagic transformation after ischemic stroke via mitochondrial defects leading to endothelial apoptosis.2014

    • Author(s)
      Mishiro K, Imai T, Sugitani S, Kitashoji A, Suzuki Y, Takagi T, Chen H, Oumi Y, Tsuruma K, Shimazawa M, Hara H
    • Journal Title

      PLoS One

      Volume: 9 Issue: 8 Pages: e103818-e103818

    • DOI

      10.1371/journal.pone.0103818

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] rt-PA 治療後の血管内治療―RCTの結果から―.2014

    • Author(s)
      髙木俊範, 吉村紳一
    • Journal Title

      分子脳血管病

      Volume: 13 Pages: 47-52

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 緊急脳血管内治療時における抗血小板薬loading dese投与後の薬効解析.2014

    • Author(s)
      榎本由貴子, 吉村紳一, 髙木俊範, 辻本真範, 石澤錠二, 岩間 亨
    • Journal Title

      JNET

      Volume: 8 Pages: 251-258

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] コラゲナーゼ誘発脳出血に対するシロスタゾールの作用.2015

    • Author(s)
      髙木俊範, 三代圭介, 辻本真範, 今井貴彦, 永嶌一紀, 嶋澤雅光, 吉村紳一, 小澤 修, 岩間 亨, 原 英彰
    • Organizer
      第40回日本脳卒中学会総会
    • Place of Presentation
      広島
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 術前t-PA静注療法が急性期再開通療法後出血に与える影響-RESCUE Japan Registryより-.2014

    • Author(s)
      髙木俊範, 吉村紳一, 榎本由貴子, 江頭裕介, 山上 宏, 坂井信幸, 岡田 靖, 北川一夫, 木村和美, 棚橋紀夫, 瓢子敏夫
    • Organizer
      第30回日本脳神経血管内治療学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-12-04 – 2014-12-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] エタノール誘発血管内皮障害に対するシロスタゾールの保護作用.2014

    • Author(s)
      髙木俊範, 三代圭介, 今井貴彦, 嶋澤雅光, 岩間 亨, 原 英彰
    • Organizer
      第26回日本脳循環代謝学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2014-11-21 – 2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 転写因子Nrf2活性化剤による脳虚血再灌流障害に対する神経保護の検討.2014

    • Author(s)
      髙木俊範, 北庄司輝, 岩脇隆夫, 嶋澤雅光, 吉村紳一, 岩間 亨, 原 英彰
    • Organizer
      第73回日本脳神経外科学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-09 – 2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Book] 循環器疾患 最新の治療2014-20152014

    • Author(s)
      髙木俊範, 吉村紳一
    • Total Pages
      5
    • Publisher
      南江堂
    • Related Report
      2014 Annual Research Report
  • [Remarks] 岐阜大学医学部脳神経外科

    • URL

      http://www.med.gifu-u.ac.jp/neurosurgery/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 岐阜大学医学部脳神経外科

    • URL

      http://www.med.gifu-u.ac.jp/neurosurgery/

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi