Development and clinical application of wire insertion force measure system for neuroendovascular treatment

• Project/Area Number: 25861271
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Nagoya University
• Principal Investigator: MATSUBARA Noriaki 名古屋大学, 医学部附属病院, 病院講師 (10422776)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: intracranial aneurysm / coil embolization / force sensor / wire / force / sensor / 国内研究発表 / 国際研究発表 / 臨床応用

Outline of Final Research Achievements

The researchers envisioned a system that would objectively register and quantify the coil insertion force in endovascular embolization for an intracranial aneurysm. Coil insertion force was measured in the clinical cases of 10 unruptured intracranial aneurysms using this sensor, and actual clinical application was investigated. The sensor consists of a hemostatic valve connected to the proximal end of a microcatheter. The sensor principle is based on an optical system. Using this, aneurysm embolizations were performed.
The sensor continuously monitored the mechanical force during the coil insertions. The sensor adequately recorded the coil insertion force during the actual clinical aneurysm embolizations and that reflected the usual clinical experience.The force sensor system adequately measured coil insertion force in actual unruptured aneurysm embolization, and usefulness of clinical application of this sensor was confirmed.

Research Products

• [Journal Article] Relationship between low response to clopidogrel and periprocedural ischemic events with coil embolization for intracranial aneurysms (2016)
  • Author(s): Asai T, Miyachi S, Izumi T, Matsubara N, Haraguchi K, Yamanouchi T, Ota K, Shintai K, Tajima H, Wakabayashi T
  • Journal Title: J Neurointerv Surg Volume: 印刷中 Issue: 7 Pages: 752-755
  • DOI: 10.1136/neurintsurg-2015-011727
  • Peer Reviewed
• [Journal Article] Results and Current Trends of Multimodality Treatment for Infectious Intracranial Aneurysms (2015)
  • Author(s): Matsubara N, Miyachi S, Izumi T, Yamanouchi T, Asai T, Ota K, Wakabayashi T
  • Journal Title: Neurologia medico-chirurgica Volume: 55 Issue: 2 Pages: 155-162
  • DOI: 10.2176/nmc.oa.2014-0197
  • NAID: 130004922274
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed / Open Access
• [Journal Article] Treatment of Symptomatic Bilateral Cavernous Carotid Aneurysms: Long-term Results of 6 Cases (2015)
  • Author(s): Uozumi Y, Okamoto S, Araki Y, Izumi T, Matsubara N, Yokoyama K, Sumitomo M, Miyachi S, Wakabayashi T
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 24 Issue: 5 Pages: 1013-1018
  • DOI: 10.1016/j.jstrokecerebrovasdis.2014.12.027
  • Peer Reviewed / Open Access
• [Journal Article] A mechanical coil insertion system for endovascular coil embolization of intracranial aneurysms (2013)
  • Author(s): Haraguchi K, Miyachi S, Matsubara N, Nagano Y, Yamada H, Marui N, Sano A, Fujimoto H, Izumi T, Yamanouchi T, Asai T, Wakabayashi T
  • Journal Title: Interventional Neuroradiology Volume: 19巻 Pages: 159-166
  • Peer Reviewed
• [Journal Article] Endovascular intervention for acute cervical carotid artery occlusion (2013)
  • Author(s): Matsubara N, Miyachi S, Tsukamoto N, Kojima T, Izumi T, Haraguchi K, Asai T, Yamanouchi T, Ota K, Wakabayashi T
  • Journal Title: Acta neurochirurgica. Volume: 155巻 Issue: 6 Pages: 1115-1123
  • DOI: 10.1007/s00701-013-1697-x
  • Peer Reviewed
• [Journal Article] Spinal cord infarction is an unusual complication of intracranial neuroendovascular intervention (2013)
  • Author(s): Matsubara N, Miyachi S, Okamaoto T, Izumi T, Asai T, Yamanouchi T, Ota K, Oda K, Wakabayashi T
  • Journal Title: Interventional Neuroradiology Volume: 19巻 Pages: 500-505
  • Peer Reviewed
• [Journal Article] The 'one and a half round microcatheterization technique' for stent-assisted coil embolization of intracranial aneurysm: technical case series (2013)
  • Author(s): Miyachi S, Matsubara N, Izumi T, Asai T, Yamanouchi T, Ota K, Oda K, Wakabayashi T
  • Journal Title: Journal of neurointerventional surgery Volume: May 30. Epub ahead of print
  • Peer Reviewed
• [Journal Article] Stent/balloon combination assist technique for wide-necked basilar terminal aneurysms (2013)
  • Author(s): Miyachi S, Matsubara N, Izumi T, Asai T, Yamanouchi T, Ota K, Oda K, Wakabayashi T
  • Journal Title: Interventional Neuroradiology Volume: 19巻 Pages: 299-305
• [Presentation] Clinical Application of Insertion Force Sensor System for Coil Embolization of Intracranial Aneurysms (2015)
  • Author(s): Matsubara N, Miyachi S, Izumi T, Tajima H, Shintai K, Ito M, Nishibori M, Imai T, Marui N, Yamada H, Wakabayashi T
  • Organizer: 13th Congress of World Federation of Interventional and Therapeutic Neuroradiology
  • Place of Presentation: オーストラリア ゴールドコースト
  • Year and Date: 2015-11-09
  • Int'l Joint Research
• [Presentation] 感染性脳動脈瘤に対するマルチモダリティートリートメント - 外科治療、血管内治療、内科的治療 治療成績とトレンドの分析 (2015)
  • Author(s): 松原功明, 宮地茂, 泉孝嗣, 山之内高志, 浅井琢美, 太田圭祐, 若林俊彦
  • Organizer: 第74回社団法人日本脳神経外科学会学術総会
  • Place of Presentation: 北海道札幌市 ロイトン札幌
  • Year and Date: 2015-10-14
• [Presentation] バルーン閉塞試験による母血管閉塞術に伴う虚血耐性の評価 (2014)
  • Author(s): 松原功明, 泉孝嗣, 太田圭祐, 新帯一憲, 田島隼人, 西堀正洋, 今井資, 伊藤真史, 宮地茂,若林俊彦
  • Organizer: 第30回NPO法人 日本脳神経血管内治療学会学術総会
  • Place of Presentation: 神奈川県横浜市 パシフィコ横浜
  • Year and Date: 2014-12-04 – 2014-12-06
• [Presentation] 脳動脈コイル塞栓術におけるガイディングシステムの検討 (2014)
  • Author(s): 松原功明, 泉孝嗣, 太田圭祐, 新帯一憲, 田島隼人, 西堀正洋, 今井資, 伊藤真史, 宮地茂,若林俊彦
  • Organizer: 第30回NPO法人 日本脳神経血管内治療学会学術総会
  • Place of Presentation: 神奈川県横浜市 パシフィコ横浜
  • Year and Date: 2014-12-04 – 2014-12-06
• [Presentation] 脳動脈瘤コイル塞栓術におけるYコネクタ型コイル挿入力測定装置の臨床応用 -手元のコイル挿入操作とコイル挿入抵抗の測定値の分析- (2014)
  • Author(s): 松原功明, 宮地茂, 泉孝嗣, 丸井直樹, 山田裕之, 永野佳孝, 太田圭祐, 佐野明人,藤本英雄, 若林俊彦
  • Organizer: 第73回社団法人日本脳神経外科学会総会
  • Place of Presentation: 東京都港区 グランドプリンスホテル新高輪
  • Year and Date: 2014-10-09 – 2014-10-11
• [Presentation] 脳動脈コイル塞栓術におけるGuiding systemの検討 (2014)
  • Author(s): 松原功明
  • Organizer: 第15回脳神経血管内治療琉球セミナー
  • Place of Presentation: 沖縄県那覇市 ホテルオーシャン
  • Year and Date: 2014-06-27 – 2014-06-29
• [Presentation] コイルデリバリーワイヤーがマイクロカテーテル内を通過する際に生じる摩擦についての基礎的研究 (2013)
  • Author(s): 松原功明, 宮地茂, 山田裕之, 丸井直樹, 泉孝嗣, 浅井琢美, 山之内高志, 太田圭祐, 若林俊彦
  • Organizer: 第29回NPO法人 日本脳神経血管内治療学会学術総会
  • Place of Presentation: 朱鷺メッセ, 新潟
• [Presentation] Mechanical Coil Insertion System for Endovascular Coil Embolization of Intracranial Aneurysms (2013)
  • Author(s): Matsubara N, Miyachi S, Haraguchi K, Nagano Y, Yamada H, Marui N, Sano A, Fujimoto H, Izumi T, Wakabayashi T
  • Organizer: 12th Congress WFITN
  • Place of Presentation: ブエノスアイレス, アルゼンチン
• [Presentation] 大型ﾜｲﾄﾞﾈｯｸ脳動脈瘤に対するステント支援コイル塞栓術 (2013)
  • Author(s): 松原功明, 宮地茂, 泉孝嗣, 浅井琢美, 山之内高志, 太田圭祐, 織田恵子, 若林俊彦
  • Organizer: 第29回NPO法人 日本脳神経血管内治療学会学術総会
  • Place of Presentation: 朱鷺メッセ, 新潟
• [Presentation] 急性頸部頸動脈閉塞に対する超急性期血管内治療 (2013)
  • Author(s): 松原功明, 宮地茂, 塚本信弘, 小島隆生, 泉孝嗣, 浅井琢美, 山之内高志, 太田圭祐, 若林俊彦
  • Organizer: 第29回NPO法人 日本脳神経血管内治療学会学術総会
  • Place of Presentation: 朱鷺メッセ, 新潟
• [Presentation] Stent/balloon combination assist technique for wide-necked basilar terminal aneurysms (2013)
  • Author(s): Matsubara N, Miyachi S, Izumi T, Asai T, Yamanouchi T, Ota K, Oda K, Wakabayashi T
  • Organizer: 12th Congress WFITN
  • Place of Presentation: ブエノスアイレス, アルゼンチン
• [Book] シミュレーションで経験する手術・IVR 内頚動脈瘤(ICA Aneurysm)のすべて-近位部(cavernous-paraclinoid) (2015)
  • Author(s): 山口竜一, 塩川芳昭, 堀内哲吉, 柿澤幸成, 本郷一博, 金太一, 品川勝弘, 岐浦禎弘, 栗栖薫, 森田明夫, 清水宏明, 柳澤俊晴, 井川房夫, 河本俊介, 西徹, 杉山拓, 中山若樹, 佐々木達也, 鈴木恭一, 松原功明, 他37名
  • Total Pages: 258
  • Publisher: メディカ出版
• [Book] 内頚動脈瘤(ICA Aneurysm)のすべて-近位部(cavernous-paraclinoid): シミュレーションで経験する手術・IVR (2015)
  • Author(s): 山口竜一, 塩川芳昭, 堀内哲吉, 柿澤幸成, 松原功明, 他36名
  • Total Pages: 258
  • Publisher: メディカ出版