Cerebral network plasticity revealed by intraoperative cortico-cortical evoked potentials

• Project/Area Number: 25861273
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Kyoto University
• Principal Investigator: Kikuchi Takayuki 京都大学, 医学(系)研究科(研究院), 助教 (40625084)
• Co-Investigator(Renkei-kenkyūsha): KUNIEDA Takeharu 京都大学, 大学院医学研究科, 講師 (60609931) ; MATSUMOTO Riki 京都大学, 大学院医学研究科, 准教授 (00378754)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: cortical function / cerebral network / evoked potential / functional plasticity / 皮質皮質間誘発電位 / 脳機能ネットワーク

Outline of Final Research Achievements

Cortico-cortical evoked potential (CCEP) was reliably recorded during neurosurgical procedure and can trace the function of language connection through dorsal language pathway. We also applied the same method for ventral language pathway and obtained CCEP on temporal cortex. The pre-and postoperative neurophychological testing revealed removal of the lesion adjacent to this pathway had an influence to the semantic processing with a laterality. We also revealed that the function improved in the postoperative course, indicating functional plasticity.

Research Products

• [Journal Article] Network specific change in white matter integrity in mesial temporal lobe epilepsy. (2016)
  • Author(s): Imamura, H., R. Matsumoto, S. Takaya, T. Nakagawa, A. Shimotake, T. Kikuchi, N. Sawamoto, T. Kunieda, N. Mikuni, S. Miyamoto, H. Fukuyama, R. Takahashi and A. Ikeda
  • Journal Title: Epilepsy Research Volume: 120 Pages: 65-72
  • DOI: 10.1016/j.eplepsyres.2015.12.003
  • NAID: 120005749848
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Different Mode of Afferents Determines the Frequency Range of High Frequency Activities in the Human Brain: Direct Electrocorticographic Comparison between Peripheral Nerve and Direct Cortical Stimulation (2015)
  • Author(s): Kobayashi K, Matsumoto R, Matsuhashi M, Usami K, Shimotake A, Kunieda T, Kikuchi T, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A
  • Journal Title: PLoS One Volume: 10 (6) Issue: 6 Pages: e0130461-e0130461
  • DOI: 10.1371/journal.pone.0130461
  • NAID: 120005674657
  • Peer Reviewed / Open Access
• [Journal Article] A possible variant of negative motor seizure arising from the supplementary negative motor area. (2015)
  • Author(s): Yamao Y, Matsumoto R, Kunieda K, Arakawa Y, Kikuchi T, Shibata S, Ikeda A, Fukuyama H, Miyamoto S
  • Journal Title: Clin Neurol Neurosurg Volume: 134 Pages: 126-129
  • DOI: 10.1016/j.clineuro.2015.04.024
  • NAID: 120005749924
  • Peer Reviewed / Open Access
• [Journal Article] New Approach for Exploring Cerebral Functional Connectivity: Review of Cortico-cortical Evoked Potential (2015)
  • Author(s): Kunieda T, Yamao Y, Kikuchi T, Matsumoto R
  • Journal Title: Neurologia medico-chirurgica Volume: 55 Issue: 5 Pages: 374-382
  • DOI: 10.2176/nmc.ra.2014-0388
  • NAID: 130005069876
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Direct Exploration of the Role of the Ventral Anterior Temporal Lobe in Semantic Memory: Cortical Stimulation and Local Field Potential Evidence From Subdural Grid Electrodes (2015)
  • Author(s): Shimotake A, Matsumoto R, Ueno T, Kunieda T, Saito S, Hoffman P, Kikuchi T, Fukuyama H, Miyamoto S, Takahashi R, Ikeda A, Lambon Ralph MA
  • Journal Title: Cerebral Cortex Volume: 印刷中 Issue: 10 Pages: 3802-3817
  • DOI: 10.1093/cercor/bhu262
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Unstable moyamoya disease: clinical features and impact on perioperative ischemic complications. (2015)
  • Author(s): Funaki T, Takahashi JC, Takagi Y, Kikuchi T, Yoshida K, Mitsuhara T, Kataoka H, Okada T, Fushimi Y, Miyamoto S.
  • Journal Title: J Neurosurg Volume: 122 Issue: 2 Pages: 400-7
  • DOI: 10.3171/2014.10.jns14231
  • Peer Reviewed / Open Access
• [Journal Article] Intracranially recorded ictal direct current shifts may precede high frequency oscillations in human epilepsy. (2015)
  • Author(s): Kanazawa K, Matsumoto R, Imamura H, Matsuhashi M, Kikuchi T, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A.
  • Journal Title: Clin Neurophysiol. Volume: 126 Issue: 1 Pages: 47-59
  • DOI: 10.1016/j.clinph.2014.05.028
  • Peer Reviewed / Open Access
• [Journal Article] Neural correlates of mirth and laughter: A direct electrical cortical stimulation study. (2014)
  • Author(s): Yamao, Y., R. Matsumoto, T. Kunieda, S. Shibata, A. Shimotake, T. Kikuchi, T. Satow, N. Mikuni, H. Fukuyama, A. Ikeda and S. Miyamoto
  • Journal Title: Cortex Volume: - Pages: 134-40
  • DOI: 10.1016/j.cortex.2014.11.008
  • NAID: 120005749923
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Voxel-based clustered imaging by multiparameter diffusion tensor images for glioma grading (2014)
  • Author(s): Inano Rika, Oishi Naoya, Kunieda Takeharu, Arakawa Yoshiki, Yamao Yukihiro, Shibata Sumiya, Kikuchi Takayuki, Fukuyama Hidenao, Miyamoto Susumu
  • Journal Title: NeuroImage: Clinical Volume: 5 Pages: 396-407
  • DOI: 10.1016/j.nicl.2014.08.001
  • NAID: 120005477685
  • Peer Reviewed / Open Access
• [Journal Article] Intraoperative dorsal language network mapping by using single-pulse electrical stimulation. (2014)
  • Author(s): Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi K, Usami K, Shibata S, Kikuchi T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S.
  • Journal Title: Hum Brain Mapp Volume: 印刷中 Issue: 9 Pages: 74-85
  • DOI: 10.1002/hbm.22479
  • Peer Reviewed / Open Access
• [Journal Article] Japanese Registry of Neuroendovascular Therapy: extracranial steno-occlusive diseases except for internal carotid artery stenosis. (2014)
  • Author(s): Kikuchi T1, Ishii A, Nakahara I, Miyamoto S, Sakai N.
  • Journal Title: Neurologia Medico-Chirurgica Volume: 54 Pages: 40-5
  • NAID: 130003383266
  • Peer Reviewed
• [Journal Article] The modulation of rolandic oscillation induced by digital nerve stimulation and self-paced movement of the finger: A MEG study. (2014)
  • Author(s): Enatsu, R., Nagamine, T., Matsubayashi, J., Maezawa, H., Kikuchi, T., Fukuyama, H., Mikuni, N., Miyamoto, S., & Hashimoto, N.
  • Journal Title: Journal of Neurological Sciences Volume: 337 Issue: 1-2 Pages: 201-211
  • DOI: 10.1016/j.jns.2013.12.011
  • Peer Reviewed
• [Journal Article] Chicken DT40 cell line lacking DJ-1, the gene responsible for familial Parkinson's disease, displays mitochondrial dysfunction. (2013)
  • Author(s): Minakawa EN, Yamakado H, Tanaka A, Uemura K, Takeda S, Takahashi R.
  • Journal Title: Neurosci Res. Volume: 77(4) Issue: 11 Pages: 228-233
  • DOI: 10.1016/j.clinph.2013.05.011
  • Peer Reviewed
• [Journal Article] Long-term seizure outcome following resective surgery for epilepsy: to be or not to be completely cured? (2013)
  • Author(s): Kunieda T1, Mikuni N, Shibata S, Inano R, Yamao Y, Kikuchi T, Matsumoto R, Takahashi J, Ikeda A, Fukuyama H, Miyamoto S.
  • Journal Title: Neurologia Medico-Chirurgica Volume: 53 Pages: 805-13
  • Peer Reviewed
• [Presentation] 「術中電気的線維追跡法を用いた腹側言語経路の検討」 (2015)
  • Author(s): 中江卓郎
  • Organizer: 日本臨床神経生理学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-11-05
• [Presentation] 「皮質皮質間誘発電位を用いた、言語機能の術中モニタリング」 (2015)
  • Author(s): 國枝武治
  • Organizer: 日本脳神経外科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2015-10-14
• [Presentation] 「意味認知の機能可塑性：側頭葉腫瘍切除症例における神経心理学的検討」 (2015)
  • Author(s): 中江卓郎
  • Organizer: 日本脳神経外科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2015-10-14
• [Presentation] 「皮質皮質間誘発電位を用いた言語機能の術中モニタリングと覚醒下手術」 (2015)
  • Author(s): 國枝武治
  • Organizer: ヒト脳機能マッピング学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-07-02
• [Presentation] 「外的入力に対する律動性皮質応答：皮質単発刺激による生理学的検討」 (2015)
  • Author(s): 中江卓郎
  • Organizer: ヒト脳機能マッピング学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-07-02
• [Presentation] Intraoperative language network monitoring by means of cortico-cortical evoked potentials
  • Author(s): Yukihiro Yamao, Riki Matsumoto, Takeharu Kunieda, Yoshiki Arakawa, Katsuya Kobayashi, Kiyohide Usami, Sumiya Shibata, Takayuki Kikuchi, Nobukatsu Sawamoto, Nobuhiro Mikuni, Akio Ikeda, Hidenao Fukuyama and Susumu Miyamoto
  • Organizer: 30th International Congress of Clinical Neurophysiology
  • Place of Presentation: Berlin
• [Presentation] Intraoperative Supplementary Motor Area (SMA) Monitoring for Medial Frontal Lesions
  • Author(s): Sumiya Shibata 1), Takeharu Kunieda 1), Riki Matsumoto 2), Yukihiro Yamao 1), Rika Inano 1),, Takayuki Kikuchi 1), Yoshiki Arakawa 1), Toshiya Sugino 1), Takeshi Funaki 1), Takafumi Mitsuhara 1), Masaomi Koyanagi 1), Kazumichi Yoshida 1), Yasushi Takagi 1), Jun Takahashi 1), Akio Ikeda 2), Susumu Miyamoto 1)
  • Organizer: 第72回日本脳神経外科学会総会
  • Place of Presentation: 横浜
• [Presentation] Intraoperative Supplementary Motor Area (SMA) Monitoring for Medial Frontal Lesions
  • Author(s): Sumiya Shibata 1), Takeharu Kunieda 1), Riki Matsumoto 2), Yukihiro Yamao 1), Rika Inano 1),, Takayuki Kikuchi 1), Yoshiki Arakawa 1), Toshiya Sugino 1), Takeshi Funaki 1), Takafumi Mitsuhara 1), Masaomi Koyanagi 1), Kazumichi Yoshida 1), Yasushi Takagi 1), Jun Takahashi 1), Akio Ikeda 2), Susumu Miyamoto 1)
  • Organizer: 第37回 日本てんかん外科学会
  • Place of Presentation: 大阪
• [Presentation] Striatal dopamine depletion lead to altered functional connectivity with the thalamus in Parkinson disease: a PET and fMRI study
  • Author(s): Rika Inano, Nobukatu Sawamoto, Takeharu Kunieda, Takayuki Kikuchi, Hayato Tabu, Tomohisa Okada, Kaori Togashi, Ryosuke Takahashi, Hidenao Fukuyama, Susumu Miyamoto
  • Organizer: ICCN2014
  • Place of Presentation: Berlin
• [Presentation] 術中MEPモニタリングにおける深部電極の活用
  • Author(s): 中江卓郎、山尾幸広、芝田純也、稲野理賀、菊池隆幸、荒川芳輝、國枝武治、三國信啓、宮本享
  • Organizer: 日本脳神経外科学会第72回学術総会
  • Place of Presentation: 横浜
• [Presentation] ステント併用コイル塞栓術後の抗血小板療法中期フォローアップ
  • Author(s): 菊池隆幸 石井暁 千原英夫 安藤充重 山尾幸広 武信洋平 宮本享
  • Organizer: 日本脳神経外科学会第72回学術総会
  • Place of Presentation: 横浜