The mechanism of repetitive transcranial magnetic stimulation (rTMS) in the brain neural network of Parkinson's disease
Project/Area Number |
25861274
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurosurgery
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Research Institution | Osaka University |
Principal Investigator |
MARUO Tomoyuki 大阪大学, 医学部附属病院, 特任研究員 (90533810)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | パーキンソン病 / 経頭蓋磁気刺激 / 脳波 |
Outline of Final Research Achievements |
The aim of our study was to evaluate the effects of Repetitive transcranial magnetic stimulation (rTMS) on cerebral blood flow (CBF) and electroencephalography (EEG) and the change of brain-derived neurotrophic factor (BDNF) in Parkinson’s disease. We used Parkinson’s model rats created by the nigra injection of 6-hydroxydopamine (6-OHDA) that enabled us to investigate CBF using laser speckle flowmetry, and electroencephalography (EEG) using BESA® .We observed that CBF in primary sensorimotor area had increased temporarily during rTMS. In the high frequency rTMS (10Hz) group, ipsilateral CBF were significantly increased after rTMS compared with before rTMS. In the low frequency rTMS(1Hz) group, contralateral CBF were increased after rTMS compared with before rTMS. However, no statistically significant differences between any measurements in sham-rTMS were found in EEG and the change of brain-derived neurotrophic factor.
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Report
(3 results)
Research Products
(69 results)
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[Journal Article] Default mode network connectivity in patients with idiopathic normal pressure hydrocephalus.2015
Author(s)
Khoo HM, Kishima H, Tani N, Oshino S, Maruo T, Hosomi K, Yanagisawa T, Kazui H, Watanabe Y, Shimokawa T, Aso T, Kawaguchi A, Yamashita F, Saitoh S, Yoshimine T.
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Journal Title
J Neurosurgery.
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Low-frequency subthalamic nucleus stimulation in Parkinson's disease: a randomized clinical trial.2014
Author(s)
Khoo HM, Kishima H, Hosomi K, Maruo T, Tani N, Oshino S, Shimokawa T, Yokoe M, Mochizuki H, Saitoh Y, Yoshimine T.
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Journal Title
Mov Disord.
Volume: 29(2)
Issue: 2
Pages: 2270-4
DOI
Related Report
Peer Reviewed
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[Journal Article] Validity, reliability and assessment sensitivity of the Japanese version of the Short-Form McGill Pain Questionnaire 2 in Japanese patients with neuropathic and non-neuropathic pain2014
Author(s)
Maruo T, Nakae A, Maeda L, Shi K, Takahashi K, Morris S, Hosomi K, Kanatani H, Matsuzaki T, Saitoh Y
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Journal Title
Pain Med.
Volume: in Press
Related Report
Peer Reviewed
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[Journal Article] Which is the Most Appropriate Disconnection Surgery for Refractory Epilepsy in Childhood?2013
Author(s)
Kishima H, Oshoni S, Tani N, Maruo T, Morris S, Khoo HM, Yanagisawa T, Shimono K, Okinaga T, Hirata M, Kato A, Yoshimine T.
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Journal Title
Neurologia medico-chirurgica
Volume: 53
Issue: 11
Pages: 814-820
DOI
NAID
ISSN
0470-8105, 1349-8029
Related Report
Peer Reviewed
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[Presentation] Frameless image-guided stereotactic implantation of depth electrodes via craniotomy for pharmacoresistant epilepsy2014
Author(s)
Khoo HM, Kishima H, Oshino S, Tani N, Maruo T, Yanagisawa T, Edagawa K, Inoue Y, Hirata M, Yoshimine T
Organizer
2014 Annual Meeting of the American Epilepsy Society
Place of Presentation
Seattle, USA
Year and Date
2014-12-05 – 2014-12-09
Related Report
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[Presentation] Frameless image-guided stereotactic implantation of depth electrodes via craniotomy for pharmacoresistant epilepsy2014
Author(s)
Khoo HM, Kishima H, Oshino S, Tani N, Maruo T, Yanagisawa T, Edagawa K, Inoue Y, Hirata M, Yoshimine T
Organizer
The 8th Asian Epilepsy Surgery Congress
Place of Presentation
Tokyo,Japan
Year and Date
2014-10-04 – 2014-10-06
Related Report
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[Presentation] Repetitive Transcranial Magnetic Stimulation over Primary Leg Motor Area in Parkinson's Disease
Author(s)
Tomoyuki Maruo,Koichi Hosomi,Toshio Shimokawa,Haruhiko Kishima,Satoru Oshino,Shayne Morris,Yu Kageyama,Masaru Yokoe,Toshiki Yoshimine,Youichi Saitoh.
Organizer
15th World Congress of Neurosurgery (WFNS2013)
Place of Presentation
Seoul,Korea
Related Report
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